摘要
目的探讨睡眠呼吸暂停低通气综合征(OSAHS)与妊娠期糖耐量异常的相关性及其可能的发病机制。方法对糖耐量异常孕妇OSAHS组25例和无OSAHS组35例进行多导睡眠监测,监测呼吸暂停低通气指数(AHI)、夜间最低脉氧饱和度(LSpO2),并同时记录年龄、孕龄、体质量指数(BMI)、糖化血清蛋白值,并测定TNF-α、IL-6水平。结果与单纯糖耐量异常组相比,合并OSAHS组AHI明显增高、LSpO2明显降低(P<0.05),IL-6和TNF-α亦增高。AHI和LSpo2与妊娠期糖耐量异常孕妇GSP、IL-6和TNF-α显著相关。IL-6和TNF-α与GSP相关,相关系数分别为0.510、0.476。结论炎症因子在糖耐量异常合并睡眠呼吸暂停综合征中起重要的作用,推测并存的OSAHS是妊娠期糖耐量异常疾病发生和发展的一个危险因素。
Objective To investigate the possible role of inflammation factors in the pathogenesis of impaired glucose tolerance（IGT） with concurrent obstructive sleep apnea/hypopnea syndrome（OSAHS） in pregnant women.Methods Twenty-five pregnant women with IGT and concurrent OSAHS and 35 pregnant women with IGT but not OSAHS were monitored for all night polysomnography（PSG）,and the apnea hypopnea index（AHI） and the lowest pulse oxygen saturation（LSpO2） were recorded.The body mass index,glycated serum protein（GSP）,interleukin-6（IL-6） and tumor necrosis factor-α（TNF-α） were measured in these women.Results IL-6 and TNF-α levels increased significantly in women with IGT and OSAHS as compared with those in women without OSAHS.AHI showed significant positive correlations to GSP,IL-6 and TNF-α,whereas LSpO2 was inversely correlated to GSP,IL-6 and TNF-α.IL-6 and TNF-α were significantly correlated to GSP,with correlation coefficients of 0.510 and 0.476,respectively.Conclusion The inflammatory factors may play important roles in IGT complicated by OSAHS in pregnant women,and as a potential risk factor,OSAHS may contribute to the occurrence of progression of IGT.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2011年第8期1357-1359,共3页
Journal of Southern Medical University
基金
国家自然科学基金(30471720)
广东省自然科学基金(04020458)~~
