摘要
目的了解2008-2010年哈尔滨市辖区医院收治的889例手足口病患者EV71病毒感染情况。方法采用两个样本率比较的假设检验,对889例手足口病患者咽拭子、粪便、肛拭子等标本RT-PCR或Real-time PCREV71核酸鉴定结果,按不同性别、不同居住地、不同年龄和不同发病时间分类进行比较,分析2008-2010年手足口病患者EV71感染情况。结果 3年合计,男性患者EV71阳性检出率高于女性（35.82%vs28.32%）,农村患者阳性检出率最高（37.60%）,城市（27.42%）与乡镇（27.36%）则相近;2-岁患者阳性检出率（37.56%）最高,其次为1-岁（34.98%）、3-岁（32.77%）和4-岁患者（32.69%）,0-岁（29.63%）和5-岁（20.88%）相对较低;7月阳性检出率（38.11%）最高,其次为6月（35.48%）、5月（34.07%）。3年实验室监测确证EV71感染率分别为31.40%、25.00%和41.24%,3年间患者样本阳性检出率差异与分类情况有关。结论 2008-2010年哈尔滨市辖区医院收治的手足口病患者EV71阳性检出率按不同性别、不同居住地、不同年龄组、不同发病时间分析,其差异与分类情况有关,手足口病患者EV71病毒检出率以农村1-4岁男性儿童最高,每年检出高峰时间不同。
Objective To analyze the age distribution and other epidemiological characteristics of EV71 infection among children with hand-foot-mouth disease（HFMD）.Methods A total of 889 clinical HFMD patients were confirmed in Harbin from 2008 to 2010.The method of RT-PCR was used to detect EV71 in the samples of throat,stool and rectal swabs.The epidemiological data of patients were analyzed for gender,age distribution and endemic features.Results The positive rate of EV71 was 32.96%（293/889） in HFMD patients.EV71 was more frequently detected in boys（35.82%,197/550） than in girls（28.32%,96/339）（P〈0.05）.The positive rate of EV71 was higher in children from rural areas（37.6%,182/484） than in children from urban areas（27.41%,111/405）（P〈0.05）.Early summer was the epidemic season of EV71 infection.July had the highest monthly rate of EV71 detection（38.11%,93/244）,followed by June（35.48%,55/155） and May（34.07%,46/135）.Among HFMD children,the positive rate of EV71 was the highest for children aged 2 years（37.56%,80/213）,followed by children aged 1 year（34.98%,78/223）,children aged 3 years（32.77%,58/177） and children aged 4 years（32.69%,34/104）.Conclusions EV71 was the major causation of HFMD among children in Harbin.Intervention measures should be taken to prevent the disease in early summer season,especially for young children in rural areas.
出处
《中国病毒病杂志》
CAS
2011年第4期300-303,共4页
Chinese Journal of Viral Diseases
基金
哈尔滨市科技创新人才研究专项资金项目(2009RFQQS007)
