摘要
目的:通过黏膜下注射5-氟尿嘧啶(5-FU)加术后灌注吡柔比星(THP)的方法,探讨联合用药在预防膀胱癌复发中的作用。方法:采用回顾性研究方法,选择我院泌尿外科行尿道膀胱肿瘤电切术(TUR-BT)后病理证实为膀胱移行细胞癌患者69例,分为单纯THP灌注组(36例),术中黏膜下注射5-FU联合术后THP灌注组(33例),随访3年,了解膀胱癌的复发率和进展率,进行临床资料分析。结果:THP组复发11例(30.6%),5-FU+THP组复发3例(9.1%),两组累积复发率比较,差异有统计学意义(P<0.05);THP组进展5例(13.9%),5-FU+THP组进展1例(3.1%),两组进展率比较,差异无统计学意义(P>0.05)。结论:黏膜下注射5-FU联合术后灌注THP预防膀胱癌复发的效果显著优于单纯灌注THP。
Objective： To discuss the curative effect of submucous injection 5-FU unite intravesical instillation therapy with THP for prevention the recurrence of bladder cancer. Methods： Retrospective study method had been choosed. 69 cases of patients who had diagnosed with bladder tumor were divided in submucous injection 5-FU unite intravesical instillation therapy with THP group＇（33 cases） and simply intravesical instillation therapy with THP group （36 cases）. The recurrence rate was counted with three years. Recurrence rate and progress rate of bladder cancer were analyzed. Results： The recurrence rate of 5-FU＋THP group was 9.1%, and the recurrence rate of the THP group was 30.6%, there was significant difference between two groups （P〈0.05）. But the rate of progress was no significantly different （P〉0.05）. Conclusion Submucous injection 5-FU unite intravesical instillation therapy with THP is more effective in preventing the recurrence of bladder cancer than pour into THP merely.
出处
《中国医药导报》
CAS
2011年第23期70-71,共2页
China Medical Herald
