摘要
目的探讨抑癌基因p16在口腔扁平苔藓(OLP)、口腔鳞状细胞癌(OSCC)中的表达及临床意义。方法采用免疫组化S-P法检测26例正常口腔黏膜组织、40例糜烂型OLP组织及40例OSCC组织p16基因的表达,并分析其临床意义。结果 p16蛋白在26例正常口腔黏膜中22例阳性表达,占84.62%,40例糜烂型OLP组织中21例p16蛋白阳性表达,占52.50%4,0例OSCC组织中9例p16蛋白阳性表达,占22.50%。p16蛋白在正常口腔黏膜组织及OSCC组织中的表达与糜烂型OLP组织中的表达差异有统计学意义(P<0.05)。p16阳性表达与OSCC组织分化程度无相关关系。结论 p16与OLP向OSCC转变有关,p16基因在OSCC的发生发展中起重要作用。
Objective To study the expression and clinical significance of p16,a novel member of anti-oncogene protein family,in oral lichen planus and oral squamous cell carcinoma.Methods Streptavidin-percocidase immunohistochemical technique（S-P method） was used to detect the expression of p16 protein in 40 cases of OSCC,40 cases of OLP tissues and 26 cases of normal oral mucosa,and their clinical significance was analyzed.Results We found that p16 expressed positively in 22 cases of 26 normal oral mucosa（84.62%）,in 21 cases of 40 OLP tissues（52.50%） and in 9 cases of 40 OSCC tissues（22.50%）.The expression of p16 were significantly different in three types of tissues（P〈0.05）.The positive expression of p16 had no relation with the differentiation of OSCC tissues.Conclusions p16 gene involves in the transformation of OLP to OSCC.p16 gene is important in the development and progress of OSCC.
出处
《医药论坛杂志》
2011年第12期42-44,共3页
Journal of Medical Forum
