摘要
目的探讨孕妇的心理应激状况与血清皮质醇及性激素的关系。方法随机抽取门诊或住院部就诊的孕妇188例。采用汉密尔顿抑郁量表、汉密尔顿焦虑量表及症状自评量表评定孕妇的心理状况；同期采血用放射免疫法测定血清雌二醇、孕激素及皮质醇水平，并对结果进行统计分析。结果抑郁与雌二醇、孕激素水平均呈负相关（r值分别为-0．180、-0．190，均P〈0．05）；焦虑仅与皮质醇水平呈正相关（t=0．153，P〈0．05）；躯体化表现、强迫症状、抑郁和焦虑均与雌二醇水平呈负相关（r值分别为-0．220、-0．196、-0．230、-0．192，均P〈0．05）；强迫症状和焦虑与皮质醇水平呈正相关（r值分别为0．015、0．011，均P〈0．05）。结论孕妇心理健康水平低下与激素有关，孕妇血浆皮质醇及性激素水平变化是其心理应激发生的可能原因。
Objective To explore the relationship between psychological change of pregnant women and their serum cortisol level as well as sexual hormone levels. Methods 188 pregnant women were randomly sampled from outpatients and inpatients in the First Affiliated Hospital of Medical College of Xi＇an Jiaotong University and 521 Military Hospital. The pregnant women＇s psychological status was assessed with Hamilton Rating Scale for Depression （ HRSD）, Hamilton Anxiety Scale （HAMA） and Symptom checklist 90 （ SCL-90 ）. The levels of serum cortisol, estradiol and pregnancy hormone in maternal blood samples taken at the same time were determined by radio-immunoassay. Results Depression was negatively correlated with estrogen and progesterone levels （ r was - 0. 180 and - 0. 190 respectively, P 〈 0.05 ）, and anxiety was positively associated with cortisol level （r =0. 153, P 〈0.05）. Somatization performance, obsessive state, depression and anxiety were all negatively correlated with estrogen level （ r was - 0. 220, - 0.196, - 0.230 and - 0. 192 respectively, P 〈 0.05）. Both obsessive state and anxiety were positively correlated with cortisol level （r was 0. 015 and 0.011 respectively, P 〈 0.05 ）. Condasion Psychological change of pregnant women is associated with sex hormones. The change of cortisol and sex hormone level is the possible cause of psychological stress.
出处
《中国妇幼健康研究》
2011年第4期435-436,445,共3页
Chinese Journal of Woman and Child Health Research
关键词
孕妇
心理变化
雌二醇
孕激素
皮质醇
pregnant women
psychological change
estrogens
progestogen
cortisol
