摘要
A series of tri\|component copolyesters composed of glycolide/lactide/caprolactone (PGLC) were obtained by bulk ring\|opening copolymerization of glycolide(GA),L\|lactide (L\|LA) and caprolactone(CL) with Sn(Oct)\-2 as catalyst for the purpose of biomedical applications.Structure of the PGLC copolyester was characterized by means of GPC,\{\}\+1H\|NMR,DSC and X\|ray diffractometry techniques.It was found that the obtained polymer was a pure copolymer that consisting of no other side\|produced polymers and the copolyester was a random copolymer that presented an amorphous structure in a large range of composition.The hydrophilicity and degradation rate of the copolyester were also studied in detail and it was found that the hydrophilicity and hydrolysis rate were improved by increasing the amount of GA.The mechanical properties of the PGLC copolyester were identified by measuring the tensile strength and the elongation at break.The elongation of the copolyester could be improved by introducing CL to the PLGA.That the PGLC copolyester was a potential biomedical material was suggested.
A series of tri\|component copolyesters composed of glycolide/lactide/caprolactone (PGLC) were obtained by bulk ring\|opening copolymerization of glycolide(GA),L\|lactide (L\|LA) and caprolactone(CL) with Sn(Oct)\-2 as catalyst for the purpose of biomedical applications.Structure of the PGLC copolyester was characterized by means of GPC,\{\}\+1H\|NMR,DSC and X\|ray diffractometry techniques.It was found that the obtained polymer was a pure copolymer that consisting of no other side\|produced polymers and the copolyester was a random copolymer that presented an amorphous structure in a large range of composition.The hydrophilicity and degradation rate of the copolyester were also studied in detail and it was found that the hydrophilicity and hydrolysis rate were improved by increasing the amount of GA.The mechanical properties of the PGLC copolyester were identified by measuring the tensile strength and the elongation at break.The elongation of the copolyester could be improved by introducing CL to the PLGA.That the PGLC copolyester was a potential biomedical material was suggested.
出处
《高分子学报》
SCIE
CAS
CSCD
北大核心
1999年第6期761-764,共4页
Acta Polymerica Sinica
基金
国家863 计划资助
关键词
乙交酯
丙交酯
己内酯
三元
共聚物
生物降解性
Glycolide,Lactide,Caprolactone,Tri\|component copolymer,Degradability
