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肝硬化患者4项凝血指标及血小板参数的临床研究 被引量:4

Clinical research of patients with liver cirrhosis and four platelet coagulation parameters
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摘要 目的探讨凝血4项和血小板参数指标在肝硬化患者病情中的变化及意义。方法对65例肝硬化患者与40例健康对照组进行凝血4项凝血活酶时间(TT)、凝血酶原时间(PT)、纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)和血小板参数血小板计数(PLT)、血小板平均体积(MPV)、血小板压积(PCT)、血小板分布宽度(PDW)指标检测。结果 PT、APTT、FIB、PLT、PCT、MPV、PDW8项指标中,PT、APTT明显延长,TT稍延长,FIB、PLT、PCT显著减少,MPV、PDW增大均有统计学意义(P<0.01),且异常程度与肝硬化的严重程度相关。结论凝血4项和血小板参数联合检验,对观察肝硬化患者肝脏功能损害程度、判断预后及指导临床用药具有重要的临床意义。 Objective To explore the parameters of coagulation and platelet four indicators in patients with cirrhosis and significance of the change in condition.Methods Totally 65 patients with cirrhosis and 40 healthy controls were four htromboplastin cltting time(TT) ,prothrombin time(PT) ,fibrinogen(FIB) ,activated partial thromboplastion time(APTT) parameters of platelet count and platelet(PLT) ,mean platelet volume(MPV) ,platelet hematocrit(PCT) ,platelet distribution width(PDW) target detection.Results PT,APTT,FIB,PLT,PCT,MPV,PDW 8 indicators in,PT,APTT was prolonged,TT slightly extended,FIB,PLT,PCT significantly decreased,MPV,PDW increases were significantly different(P0.01) ,and the unusual degree of correlation with the severity of liver cirrhosis.Conclusions The blood coagulation and platelet parameters of four joint tests,observation of patients with cirrhosis of the liver function damage,prognosis,clinical treatment has important clinical significance.
作者 王景顺
出处 《医药论坛杂志》 2011年第10期85-86,共2页 Journal of Medical Forum
关键词 肝硬化 凝血功能 血小板参数 Cirrhosis Coagulation Platelet parameters
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