摘要
目的研究中老年慢性肾衰竭CKD3期～CKD5期患者骨质疏松情况,分析骨质疏松与慢性肾衰竭、年龄、体重指数及性别的相关性,探讨慢性肾衰竭所致骨质疏松的早期表现。方法①采用双能X线骨密度仪测定腰椎正位(L1～L4)和股骨颈、Ward's三角、大粗隆的骨密度;②测量143例中老年慢性肾衰竭患者及对照组165例骨密度(BMD)值,采用病例对照法分析慢性肾衰竭对骨质疏松发病率的影响;③采用Logistic多元回归法分析慢性肾衰竭、年龄、性别及体重指数对骨质疏松的影响。结果①中老年慢性肾衰竭患者的骨质疏松发病率为79.02%,明显高于对照组(47.88%);②CKD3、4、5期患者中,骨质疏松患病率随肾功能减退而逐渐增加;骨质疏松与慢性肾衰竭及年龄正相关,与体重指数负相关;④Ward's三角的骨质疏松患病率及骨量减少程度高于股骨其他部位及腰椎。结论慢性肾衰竭是骨质疏松的重要影响因素。Ward's三角可作为早期诊断骨质疏松的首选检查部位。
Objective To study the osteoporosis status in middle- and elder-aged patients with stage 3-5 of chronic renal failure, and to analyze the correlation among osteoporosis and chronic renal failure, age, body mass index, and gender, and to explore the early manifestations of osteoporosis in chronic renal failure patients. Methods 1 ） Dual-energy X-ray absorptiometry was used to measure the bone mineral densities （BMI）） of the lumbar vertebra （LI-L4 ）, the femoral neck, the Ward＇ s triangle, and the femoral trochanter. 2） BMDs were measured in 143 middle- and elder-aged patients with chronic renal failure and 165 controls. Case-control analysis was used to show the effect of chronic renal failure on the incidence of osteoporosis. 3 ） Logistic multiple regression analysis was used to analyze the contributions of chronic renal failure, age, gender, and body mass index to osteoporosis. Results 1 ） The middle- and elder-aged patients with chronic renal failure had a significantly higher incidence of osteoporosis （ 79.02% ） than the controls （47.88% , P 〈0. 01 ）. 2） In patients with stage 3, 4, and 5 of chronic kidney disease （CKD）, the incidence of osteoporosis increased with the gradual failure of the renal function. Osteoporosis was positively correlated with the degree of renal failure and age, and was negatively correlated with body mass index. 3） Osteoporosis incidence and bone loss were higher in the Ward＇ s triangle than those in the other parts of femur and the lumbar vertebra. Conclusion Chronic renal failure is an important predisposing factor of osteoporosis. The Ward＇s triangle can be used as the first examination location for early diagnosis of osteoporosis.
出处
《中国骨质疏松杂志》
CAS
CSCD
2011年第7期583-586,共4页
Chinese Journal of Osteoporosis
