摘要
目的：探讨血清及皮损组织液可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）水平与银屑病活动性和型别的关系。方法：采用双抗体夹心法测定不同类型银屑病患者治疗前后血清及皮损组织液ｓＩＬ－２Ｒ水平。结果：寻常型（ＰＶ）、红皮病型（ＰＥ）、脓疱型（ＰＰ）和关节型（ＰＡ）银屑病患者血清ｓＩＬ－２Ｒ水平在进展期均高于正常对照组（Ｐ＜０．０５），皮损消退后，则明显下降（Ｐ＜０．０５）；但在ＰＥ、ＰＰ和ＰＡ患者皮损组织液中的水平则无明显下降（Ｐ＞０．０５）。结论：血清及皮损组织液ｓＩＬ－２Ｒ水平与ＰＶ的临床活动性显著相关，但与ＰＥ、ＰＰ和ＰＡ的活动性无明显关系。
To assess the relationship between sIL - 2R levels and the clinical activity and type of psoriasis. Method: Sandwich ELISA with monoclonal and polyclonal antibodies was used to measure the sIL - 2R levels in sera and skin lesion tissue fluid from patients with psoriasis. Results: The serum level of sIL - 2R of all patients at progressive stage was higher than that of normal control (p < 0. 05 ). There was no obvious change observed in level of sIL -- 2R in tissue fluid from PE, PP, and PA patients before and after treatment (p > 0. 05). Conclusion: The data indicated that the levels of slL - 2R in sera and skin lesion tissue fluid might relate to the clinical activity of PV, but did not relate to that of PE, PP and PA.
出处
《中国麻风皮肤病杂志》
北大核心
1999年第2期18-19,共2页
China Journal of Leprosy and Skin Diseases
