摘要
目的:探讨血小板活化因子(PAF)、肿瘤坏死因子-α(TNF-α)及血小板源生长因子(PDGF)水平变化在毛细支气管炎并急性心衰的变化,探讨它们在该病的发病中的作用方法:58例心衰组患儿分别于治疗前和临床症状消失后采用双抗体夹心ABC-ELISA法检测PAF、TNF-α及PDGF血清含量,设正常对照组40例比较。结果:心衰组PAF治疗前为370.57±23.6ng/L,明显高于对照组的56.78±19.6ng/L,组间比较差异具有非常显著性意义(t=15.95,P<0.001);治疗后恢复至49.63±14.5 ng/L,与正常对照差异不明显;治疗前后比较,差异具有非常显著性意义(t=3.70,P<0.001)TNF-α治疗前为457.4±40.5 ng/L,明显高于对照组的148.8±21.6ng/L,组间比较差异具有显著性意义(t=2.135,P<0.05);治疗后恢复至162.6±37.61ng/L,与正常对照差异不明显;治疗前后比较,差异具有非常显著性意义(t=7.25,P<0.01)。PDGF治疗前为596.23±199.43)ng/L,较对照组259.76±69.58ng/L增高,组间比较,差异具有非常显著性意义(t=25.52,P<0.01);治疗后降为272.83±116.96ng/L,较治疗前明显恢复,组间比较差异均具有显著性意义(t=7.66,P<0.01)结论:结果表明,PAF、TNF-α、PDGF作为炎症介质不仅参与心衰的发病过程。
Objective： The present study was designed to study the level changes and effects of platelet-activating factor, tumor necrosis factor-a and platelet-derived growth factor in Bronchiolitis with acute heart failure. Methods： Set heart failure group （n=58 cases）, and healthy control group （n=40 cases）. Collect the patients＇ blood samples before treatment and after clinical symptoms disappeared. The levels of serum PAF, TNF-a and PDGF were detected by ABC-ELISA method. Results： Before treatment, PAF of heart failure group was significantly higher than healthy control group. The difference between groups was statistically significant （t=3.70, P〈0. 001）. After clinical symptoms disappeared, PAF of heart failure group had no statistically significant difference with healthy control group. Before and after treatment, the difference was statistically significant （t=3.70, P〈0.001）. TNF-α of heart failure group was significantly higher than healthy control group. The difference between groups was statistically significant （t=2.135, P〈0.05）. After clinical symptoms disappeared, TNF-a of heart failure group had no statistically significant difference with healthy control group. Before and after treatment, the difference was statistically significant （t=7.25, P〈0.01）. PDGF of heart failure group was significantly higher than healthy control group. The difference between groups was statistically significant （t=-25.52, P 〈0.01）. Before and after treatment, the difference was statistically significant （t=7.66, P 〈0.01）. Conclusion： As inflammatory mediators, platelet-activating factor, tumor necrosis factor-α and platelet-derived growth factor involved in the pathogenesis of heart failure, and abnormal extracellular matrix has an important part in the pathogenesis of heart failure.
出处
《现代生物医学进展》
CAS
2011年第15期2885-2887,共3页
Progress in Modern Biomedicine
