摘要
目的探讨中国人群IgE高亲和力受体β链（FcεRIβ）基因-6843G/A多态性与哮喘易感性的关系。方法检索PubMed、Embase、中国学术期刊网全文数据库（CNKI）、万方数据检索系统及维普数据库,收集研究中国人群FcεRIβ基因-6843G/A多态性与哮喘易感性关系的文献进行Meta分析,末次检索时间为2009年10月1日。病例组和对照组基因型分布的比值比（OR）及95%CI为效应指标,应用RevMan 4.2.8软件对各研究原始数据进行统计学分析并检验异质性,采用STATA10.0软件检验发表偏倚。结果根据纳入排除标准,共有9篇文献研究-6843G/A多态性位点,G携带者（GG＋GA）的哮喘发病风险较AA野生型纯合子（AA）增加49%（OR=1.49,95%CI1.01~2.22）。亚组分析显示,G携带者成年发病的风险明显增高（OR=1.83,95%CI1.32~2.52）,而儿童发病风险无显著性差异（OR=1.19,95%CI0.68~2.08）。结论中国人群FcεRIβ基因-6843G/A多态性与哮喘易感性密切相关,突变子G携带者的哮喘发病风险较高。
Objective To investigate the association between the-6843G/A polymorphism of high-affinity IgE receptor β chain（FcεRIβ） gene and asthma susceptibility in Chinese population.Methods We searched Pubmed,EMBASE,CNKI（Chinese National Knowledge Infrastructure）,Wanfang Datebase,VIP Database up to October 1,2009.Statistical analysis was performed with the software program RevMan 4.2.8 and STATA 10.0.Results A total of 9 case-control studies were included in the meta-analysis.The results indicated that the G allele carriers had a 49% increased risk of asthma in Chinese population（GG＋GA vs.AA：OR=1.49,95%CI 1.01-2.22）.In the subgroup analysis,the results indicated that the polymorphism was associated with increased risk of asthma in the adults（GG＋GA vs.AA：OR=1.83,95%CI 1.32-2.52）,but not in children（GG＋GA vs.AA：OR=1.19,95%CI 0.68-2.08）.Conclusion The-6843G/A polymorphism of FcεRIβ gene is associated with increased asthma susceptibility in Chinese population.
出处
《中国呼吸与危重监护杂志》
CAS
2011年第4期321-324,共4页
Chinese Journal of Respiratory and Critical Care Medicine
