摘要
目的:分析脑出血发病的昼夜变化规律与卒中传统危险因素之间的相关性。方法:前瞻性登记发病时间明确的758例脑出血患者,计算在早上(05:00-10:00)、下午(11:00-16:00)、晚上(17:00-22:00)和夜间(23:00-04:00)发病的频数,行频数分布拟合优度x2检验,检验脑出血发病昼夜变化规律;用多分类Logistic回归分析发病昼夜变化规律与卒中传统危险因素的关系。结果:①早上和晚上是发病的两个高峰,分别占31.0%和35.9%,夜间和下午是两个低谷;年轻(≤60岁)者,晚上是发病最高峰,年老(>60岁)者早上是发病最高峰;②无论有或无高血压、糖尿病、吸烟、饮酒和卒中史危险因素,脑出血发病昼夜变化规律与总体相一致;③Logistic回归显示,性别、高血压病、糖尿病、吸烟、饮酒史和卒中史与脑出血的发病昼夜变化规律不存在相关性。结论:脑出血的发病呈现早上-晚上双峰分布的昼夜变化规律,年轻者表现为晚高峰优势的特点,年老者表现为早高峰优势的特点,脑出血发病昼夜变化规律与传统卒中危险因素不相关。
Objective： To analysis the relationship between circadian variation of intrac-erebral hemorrhage（ICH） and traditional risk factors of stroke.Methods： Prospective regis-tration of 758 cases with intra-cerebral hemorrhage,whose onset time was confirmed was selected.The cerebral hemorrhage frequency during morning（05：00-10：00）,afternoon（11：00-16：00）,evening（17：00-22：00） and night（23：00-04：00） and was caleulated and cerebral hemorrhage changes of diurnal variation with the frequency distribution of goodness of fit x2 test were tested.Multinomial logistic regression was used to analysis the relationship betwween circadian variation and traditional risk factors of stroke.Results： ①Morning and evening were two onset peak,accounting for 31.0% and 35.9% respectively;night and afternoon were two onset low valley.For age≤60 years,evening was the peak of onset,and age60 years,morning was the peak.②Circadian variation of ICH was consistent with the presence or absence of a history of hypertension,diabetes mellitus,smoking,alcohol intake and stroke history.③Logistic regression analysis showed that there was no correlation between conventional risk factors（gender,hypertension,diabetes mellitus,smoking,alcohol intake and stroke history） and circadian variation of ICH.Conclusion：There is a morning-evening bimodal distribution of circadian variation for the onset time of ICH,evening is the peak of onset for younger patients and morning is the peak for elder,the circadian variation is not related with traditional stroke risk factors.
出处
《温州医学院学报》
CAS
2011年第4期311-314,320,共5页
Journal of Wenzhou Medical College
基金
温州市科技局科研基金资助项目(Y2004A014
20070038)
关键词
脑出血
昼夜节律
危险因素
intra-cerebral hemorrhage
circadian variation
risk factors
