摘要
目的应用频域相干光断层扫描（OCT）技术评价Stargardt病患者黄斑区视网膜容积与中心视力之间的关系。方法回顾性病例系列研究。收集10例（20只眼）Stargardt病的临床资料进行回顾性分析。所有患者均使用频域OCT分别测量黄斑中心凹区视网膜厚度、黄斑中心凹区光感受器细胞内外节缺失宽度、黄斑中心凹区直径3mm和1mm范围内的视网膜容积。运用线性回归分析法，比较最小分辨角对数（10gMAR）视力与黄斑中心凹区视网膜厚度、黄斑中心凹区光感受器细胞内外节（IS／OS）缺失宽度、黄斑中心凹区直径3mm和1mm范围内视网膜容积的关系。结果18只眼的logMAR视力为0．30～1．22，黄斑中心凹区光感受器细胞内外节缺失宽度为847～5306μm，黄斑中心凹区视网膜厚度为20～126μm，黄斑中心凹区直径3mm和1mm范围内的视网膜容积分别为1．06～1．76mm3、0．06～0．13mm3。logMAR视力与黄斑中心凹区光感受器细胞内外节缺失宽度呈正相关（r=0．695，P〈0．05），与黄斑中心凹区视网膜厚度呈负相关（r=-0．601，P〈0．05），与黄斑中心凹区直径3mm范围内的视网膜容积呈负相关（r=-0．725，P〈0．05），与黄斑中心凹区直径1mm范围内的视网膜容积无相关性（r=-0．364，P〉0．05）。结论频域OCT技术可以清晰观察Stargardt病患者各层视网膜结构，频域OCT检测获得的黄斑区视网膜容积与中心视力间存在一定的相关性。
Objective To assess the relationship between central visual acuity and retinal volume of macular fovea in patients with Stargardt disease by spectral-domain optical coherence tomography （SD OCT）. Methods It was a retrospective case series study. Twenty eyes of 10 patients with Stargardt disease were investigated by three-dimensional spectral-domain optical coherence tomography. SD OCT images were obtained and retrospectively analyzed. The retinal volumes of macular fovea were measured by SD OCT, whose diameters were set as 3 mm and 1 mm separately （ volume 3 and volume 1 ）. The retinal thickness of macular fovea （macular thickness） and the width of IS/OS conjunction loss of macular fovea （ IS/OS loss） were also measured by SD OCT. We correlated the logMAR BCVA with IS/OS loss, macular thickness, volume 3 and volume 1 by linear regression analysis. Results LogMAR BCVA was from 0. 3 to 1. 22. IS/OS loss was from 847 μm to 5306 μm. Macular thickness was from 20μm to 126 p,m. Volume 3 and volume 1 was from 1.06 to 1.76 mm3 and 0. 06 to 0. 13 mm3. LogMAR BCVA correlated with the IS/OS loss （ r = 0. 695, P 〈 0. 05 ）, macular thickness （ r = - 0. 601, P 〈 0. 05 ）, and volume 3 （ r = -0. 725, P 〈 0. 05 ）. LogMAR BCVA did not correlate with volume 1 （ r = - 0. 364, P 〉 0. 05 ）. Conclusions SD OCT could demonstrate the retinal structure of Stargardt disease clearly. The retinal volume of maeular fovea accessed by SD OCT correlated with the visual acuity of Stargardt disease.
出处
《中华眼科杂志》
CAS
CSCD
北大核心
2011年第7期628-632,共5页
Chinese Journal of Ophthalmology
关键词
相干光断层扫描
黄斑
视网膜
Optical coherence tomography
Macular lutea
Retina
