摘要
目的观察短期应用胰岛素泵治疗对初诊2型糖尿病患者血糖、胰岛β细胞功能和胰岛素敏感性的影响。方法用胰岛素泵对72例初诊2型糖尿病患者进行2周的持续皮下胰岛素输注(CSII),观察并记录治疗前后空腹血糖(FPG)及餐后2h血糖(2hPG)、糖化血红蛋白A1c(HbA1c)、空腹胰岛素(FINS)、餐后2h胰岛素(2hINS)、胰岛素分泌指数(HOMA-β)、早期胰岛素分泌指数胰岛素抵抗指数(HOMA-IR)。计算胰岛素及葡萄糖曲线下面积(AUCI,AUCG)。结果 CSII治疗能快速稳定控制血糖,治疗2周后FINS及HOMA-β明显上升,HOMA-IR明显下降(P<0.01)。结论短期CSII治疗对2型糖尿病有快速稳定血糖、改善胰岛β细胞功能和降低胰岛素抵抗的作用。
Objective To observe the effect of short-term continuous subcutaneous insulin infusion （ CSII ） on blood glucose, betacell function and insulin resistance in patients with newly-diagnosed type 2 diabetes mellitus. Methods Seventy-two patients with newly-diagnosed type 2 diabetes mellitus receiving two weeks of CSII therapy were analyzed . The levels of the fasting plasma glucose （FPG）,2 hours postpradial glucose （2hPG）, and glycosylated hemoglobin Alc（ HbAlc ）, fast insulin （FINS）,2 hours postpradial insulin and insulin secretion indexes （ HOMA-β ） and insulin resistance index （ HOMA-IR ） were determined and compared before and after CSII. Results The level of blood glucose was well stably controlled by CSII. The levels of FINS, HOMA-β were increased significantly two weeks after intensive treatment with CSII. The HOMA-IR were decreased significantly. Conclusion Short-term CSII intensive treatment can stably control the level of blood sugar, improve the function of beta-cell and reduce the resistance to insulin in type 2 diabetic patients.
出处
《中国现代医生》
2011年第20期50-51,61,共3页
China Modern Doctor
关键词
2型糖尿病
持续皮下胰岛素输注
胰岛Β细胞功能
胰岛素抵抗
Type 2 Diabetes
Continuous subcutaneous insulin infusion
Islet β cell function
Insulin resistance
