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ADAMTS-4在膝骨关节炎关节液中的表达和意义 被引量:4

Expression and Significance of ADAMTS-4 in Synovial Fluid of Knee Osteoarthritis
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摘要 目的探讨ADAMTS-4在膝骨关节炎(OA)关节液中的表达和意义.方法单侧膝OA87例中,早期为45例,中晚期为42例.检测其患侧膝关节液中ADAMTS-4水平.以健康志愿者30例为正常对照组.应用酶联免疫吸附试验(ELISA)检测ADAMTS-4在关节液中的表达,以ELISA光密度(OD)值代表所测各项在关节液中的表达水平.结果膝OA患者关节液中ADAMTS-4表达水平均高于正常对照组(P<0.05);而正常对照组关节液中仅有少量聚蛋白多糖酶的表达.结论 ADAMTS-4水平在膝OA早期和中晚期关节液中均有高表达,检测关节液中ADAMTS-4表达水平有助于病情早期诊断. Objective To investigate expression and significance of ADAMTS-4 in synovial fluid of knee osteoarthritis.Method Among 87 patients with single-side knee osteoarthritis,45 of them suffered from early-stage knee osteoarthritis,and 42 of them from medium-later-stage knee osteoarthritis.The levels of ADAMTSs in synovial fluid of patitents were determined.30 healthy volunteers were selected into the control group.Results ADAMTSs-4 in synovial fluid had higher expression in the early stage OA group than in the late stage OA group(P0.05).Only a few ADAMTS-4 in synovial fluid were expressed in the control group.Conclusion ADAMTS-4 in synovial fluid have high expression in the early stage and late stage OA groups,and ADAMTS-4 has value in the early diagnosis of OA.
出处 《昆明医学院学报》 2011年第6期59-61,共3页 Journal of Kunming Medical College
基金 昆明医学院联合基金资助项目(2008CD048)
关键词 膝骨关节炎 关节液 聚蛋白多糖酶 Knee osteoarthritis Synovial fluid ADAMTS-4
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