摘要
目的 评价我国人群心肌梗塞的发生与血小板膜糖蛋白 (glycoprotein,GP)Ib基因多态性的关系。方法 采用病例对照研究 ,选择 10 0例确诊心肌梗塞的患者 (急性或陈旧性 )和 10 4例无心脏病史者作对照 ,用PCR SSP的方法进行血小板GPIbα链的基因多态性检测。结果 对照组无Met/Met纯合子 ,Thr/Met占 16.3 % ;心肌梗塞组Thr/Met+Met/Met共占 3 0 % ,与对照组相比 ,P =0 .0 2 ,比数比 (oddsratio,OR)为 2 .2 (95 %可信区间 1.1～4 .3 )。在≤60岁发生心肌梗塞的患者Thr/Met+Met/Met之和的频率(42 .2 % )更明显高于≤ 60岁的对照组 (14 .5 % ) (P =0 .0 0 2 ,OR =4 .3 ,95 %可信区间1.7～10 .8)。结论 血小板GPIb中Met等位基因与心肌梗塞之间呈显著的相关性 ,在≤60岁的人中 ,此种相关性更强。
Objective Platelet glycoprotein (GP) Ib/IX complex is the receptor of von Willebrand factor (vWF), which mediates shear stress dependent platelet activation. It may be involved in the pathogenesis of acute coronary syndrome. The correlation between myocardial infarction (MI) and platelet GPIb polymorphism was assessed.Methods Genotypes of the α chain of the receptor (GP Ibα, 145 Thr/Met)were determined in 100 patients with MI as well as in 104 individuals from the general population with no history of any heart disease with PCR SSP (sequence specific primers). Results The prevalence of the Met/Met(M/M) and Thr/Met (T/M) genotype in MI patients was significantly different from that in the control group (30% vs 16.3%, P =0.02, odds ratio= 2.2 , 95%CI 1.1-4.3). And the frequency of M/M and T/M was significantly higher in patients aged ≤60 years (42.2%) than in the control subjects aged ≤60 years (14.5%) ( P =0.002, odds ratio=4.3, 95%CI 1.7-10.8). Conclusion The study suggests that there is a strong correlation between the presence of the Met allele in GP Ibα and myocardial infarction, and this correlation is stronger in patients who had had myocardial infarction before the age of 60 years. The results need to be confirmed in a large scale study.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
1999年第6期436-439,共4页
Chinese Journal of Cardiology
关键词
心肌梗塞
血小板膜糖蛋白
基因多态性
myocardial infarction platelet membrane glycoproteins genes
