摘要
目的:探讨氟尿嘧啶治疗妊娠滋养细胞肿瘤的最佳剂量范围。方法:选取2007年1月～2010年12月间我院收治的妊娠滋养细胞肿瘤患者的临床资料,通过分析疗效与不良反应的相关性,得出最佳给药剂量范围。结果:经过分析,氟尿嘧啶按体表面积给药剂量与化疗的副反应呈显著性相关;各剂量分组在骨髓抑制、恶心呕吐、腹泻、口腔溃疡等不良反应的比较中差异有统计学意义(P<0.05),而对于肝功能SGPT的升高以及疗效的比较中,差异无统计学意义(P>0.05)。结论:随着氟尿嘧啶给药剂量的增加,副反应也增加,而疗效却无显著性差异,因此氟尿嘧啶的给药剂量范围不应大于600-800mg/(m2·d)。
Objective：To investigate the optimal dose of fluorouracil in the chemotherapy of gestational trophoblastic neoplasia. Method：The clinical data of 141 patients diagnosed GTN from Jan 2007 to Dec 2010 in our hospital was studied. The associativity between therapeutic effect and adverse reaction of fluorouracil was analyzed. Results ： There was a statistically significant correlation between the fluomuraeil dose and side effect of chemotherapy （ P 〈 0. 05 ）. The adverse reactions between different fluorouracil doses were statistically different on the mye]osuppression, nausea and vomiting, diarrhea and oral ulcer （ P 〈 0. 05 ）. These was no significant differences on the liver SGPT and efficacy （ P 〉 0.05 ）. Conclusion： With the fluorouracil dose increasing, the adverse reaction of tluorouxacil is also increased hut the therapeutic effect is no changed. The dose of fluorouraeil should not exceed 600 - 800mg/（ ^m2· d）.
出处
《医学信息（中旬刊）》
2011年第7期3239-3240,共2页
Medical Information Operations Sciences Fascicule
关键词
氟尿嘧啶
妊娠滋养细胞肿瘤
副反应
Fluorouraeil
Gestational trophoblastie neoplasia
Adverse reaction
