摘要
目的:研究依那普利与小剂量氢氯噻嗪的联合利用的疗效。方法:抽取我院治疗的160例高血压患者,其都符合1999年修订的WHO高血压诊断标准。对所有的高血压患者都进行三天的停药处理,之后进行联合用药治疗。在治疗之前为患者检测血尿常规、电解质、肾功能、血脂、心电图以及血糖,在治疗过程中,要求患者每天口服12.5mg氢氯噻嗪一次,每天口服依那普利两次,依那普利每天口服的剂量从2.5mg逐渐递增到10mg。依那普利和小剂量氢氯噻嗪的联合治疗一般是四个星期为一个疗效。在此期间,每周都为患者进行血尿常规、电解质、肾功能、血脂、心电图以及血糖的检测。结果:经由四个星期的治疗,患者的平均血压由[(20.4±0.8)/(13.3±0.8)]kPa减少到了[(17.5±1.1)/(10.8±1.2)]kPa,患者血压下降变化具有显著性统计意义(即P小于0.01)。其中显效的104例,有效的40例,无效的16例,其中总有效率为百分之九十。同时,在服药后未见血尿常规、电解质、肾功能、血脂、心电图以及血糖有明显的变化。结论:利用依那普利与小剂量氢氯噻嗪对高血压患者的联合治疗疗效突出,具有临床意义。
Objective： Studying the effectiveness of combined utilization of Enapril and small dose of hydroehlorothiazide. Method ： Select 160 cases of hyperpieties who are cured in our hospial and are all in accordance with WHO hyperlension diagnostic criteria revised in 1999. Apply drug discontinuance on all hpterpietics for three days and combined medication on them. Before treatment test their urine, electrolyte, renal function, blood fat, electrocardiogram and blood sugar, and during the treatment requires them to take 12.5mg hydroehlorothiazide orally for one time and enapril for two times per day. The dose of orally taken enapril per day is increasing from 2.5mg to 10 mg. The combined treatment of enapril and small dose of hydroehlorothiazide is generally one curative effect of four weeks. During this period, conduct urine, electro- lyte, renal function, blood fat, electrocardiogram and blood sugar tests for the patients every week. Result： After the four- week treatment, the average blood pressure of patients has reduced from [ （20.4 ± 0.8 ） / （ 13.3 ± 0.8 ） ] kPa to [ （ 17.5 ± 1.1 ） / （ 10.8± 1.2） ] kPa. The descending change of blood pressure for patients is of re- markable statistical significance （ i. e. P is less than 0.01 ）. Among them there are 104 cases of excellent patients ,40 eases of effective patients, and 16 eases of ineffective patients. The overall effective rate is 90%. At the same time, after taking medicine there is no remarkable change in urine, electrolyte, renal function, blood fat; eleetreear- diogram and blood sugar. Conclusion： Making use of enapril and small dose of hydrochlorothiazide is of outstanding curative effects and clinical significance to the combined treatment of hyperpietics.
出处
《医学信息（中旬刊）》
2011年第7期2870-2870,共1页
Medical Information Operations Sciences Fascicule
关键词
高血压
联合用药
疗效分析
Hypertension
Drug Combination
Analysis of Curative Effect
