摘要
目的:对咳嗽变异性哮喘患儿进行血清微量元素铁、锌及T淋巴细胞亚群检测,发现咳嗽变异性哮喘患儿血清微量元素及细胞免疫特点。方法:选出30例咳嗽变异性哮喘患儿,采用spectraspan-V型三电极等离子体原子发射直读光谱仪测定铁、锌,采用链霉卵白素(SAP)法检测T细胞亚群CD3、CD4、CD8的阳性率,对结果进行两组比较。结果:咳嗽变异性哮喘患儿铁、锌与对照组比较降低,患儿T淋巴细胞亚群与对照组比较CD3、CD4降低,CD8增高,CD4/CD8比值减小,差异有显著性(P<0.05)。结论:咳嗽变异性哮喘患儿与微量元素缺乏及免疫功能紊乱关系密切,且微量元素缺乏导致免疫功能低下,从而造成患儿容易病毒感染,进一步发生气管粘膜的损伤,促进咳嗽变异性哮喘的发生。
Objective：Detect serum trace elements and T lymphocyte subsets of cough variant asthma in children,Found the characteristics of cellular immunity and serum trace elements with cough variant asthma.Methods Selected 30cases of cough variant asthma in children,By spectraspan-V-type three-electrode plasma atomic emission spectrometer direct reading iron,zinc,Detection the positive rate of T cell subsets CD3、CD4、CD8using streptavidin（SAP）method.Compare the results between the two groups.Results Cough variant asthma iron,zinc compared with the control group decreased,The positive rate of T cell subsets CD3、CD4was lower,CD8was higher CD4/CD8was lower.the positive rate between the two groups had significant differences（P0.05）.Conclusion Cough variant asthma in children with micronutrient deficiencies and immune disorders are closely related,and trace element deficiency causes immune dysfunction,resulting in easy to virus infection in children,and further damage to tracheal mucosa,promote the occurrence of cough variant asthma.
