摘要
目的 探讨外阴、宫颈人乳头瘤病毒 (HPV)感染与局部组织病理学改变的关系 ,评价组织病理学检查在HPV感染诊断中的意义。方法 采用原位杂交和聚合酶链反应 (PCR)方法 ,对 112例外阴、宫颈病变进行了HPV6B/ 11、16、18型DNA检测 ,并对HPVDNA阳性的病变进行组织病理诊断。结果 HPVDNA阳性者 82例 ,占73 .2 1% ,82例中 ,组织病理诊断为尖锐湿疣者 2 2例 ,其余 60例组织病理学均无明显尖锐湿疣病变 ,而为宫颈腺性糜烂、化生、上皮内瘤变 (CIN1～CIN3)以及外阴、宫颈鳞状细胞癌 ,甚至是正常宫颈。结论 HPV感染不仅与尖锐湿疣有关 ,还与上皮内瘤变及癌有关。因此 ,对外阴、宫颈病变除了常规的组织检查外 ,还应检测HPVDNA。
Objective To understand the relationship between vulva/cervix and human papilloma virus infection, and evaluate the score of local histopathologic change in diagnosis of HPV infection. Methods HPV DNA of type 6B/11, 16, 18 were detected in vulva/cervical lesions of 112 cases with in situ hybridization and polymerase chain reaction. The tissues containing HPV DNA were investigated with histopathologic method. Results 82 of 112(73.21%) were positive for HPV DNA. Of 82 cases, 22 patients were diagnosed as condyloma acuminatum, others, cervical glandular erosion, metaplasia, intraepithelial neoplasia vulval/cervical squamous cell cancer, as well as normal tissue. Conclusions HPV infection relates not only to condyloma acuminatum, but also to other cervical lesion. Therefore, routine histopathologic examination and detection of HPV DNA should be simultaneously performed on vulval/cervical tissue.
出处
《徐州医学院学报》
CAS
1999年第6期439-441,共3页
Acta Academiae Medicinae Xuzhou
关键词
组织病理
诊断
外阴
宫颈
乳头瘤病毒
尖锐湿疣
Histopathologic diagnosis Vulva/Cervix Human papilloma virus DNA Condyloma acuminatum Intraepithelial neoplasia Squamous cell cancer
