摘要
目的探讨辛伐他汀在治疗慢性阻塞性肺疾病合并肺动脉高压患者肺功能、血浆内皮素等变化的疗效。方法临床统计38例慢性阻塞性肺疾病合并肺动脉高压患者,随机分为辛伐他汀治疗组和氨氯地平对照组各19例,治疗组每晚口服辛伐他汀20mg一次,对照组每日口服苯磺酸氨氯地平5mg。结果治疗组中总治疗有效率为66.67%,对照组中总治疗有效率为52.94%。治疗组与对照组相比,其呼吸困难改善更为明显,肺功能改善也更为明显。结论辛伐他汀治疗慢性阻塞性肺疾病合并肺动脉高压,能提高疗效,改善肺功能。
Objective To study the simvastatin in the treatment of chronic obstructive pulmonary disease merge patients with pulmonary arterial hypertension plasma endothelin lung function, the curative effect of such change. Methods Clinical statistic 38 cases of chronic obstructive pulmonary disease patients with pulmonary arterial hypertension, combined with simvastatin randomly divided into the treatment group and control group each amlodipine treatment group （19 cases）, oral simvastatin every 20rag once, the control group daily oral benzene sulfonic acid amlodipine 5rag. Results In total treatment efficient treatment group and control for 66.67% in total treatment 52.94% laseris. The treatment group compared with control, and its difficulty breathing improvement is more apparent, improve lung function is more obvious. Conclusion Simvastatin combined treatment of chronic obstructive pulmonary dlsease pulmonary hypertension, can raise curative effect, improve lung function.
出处
《中国医药指南》
2011年第20期23-24,共2页
Guide of China Medicine
关键词
辛伐他汀
慢性阻塞性肺疾病
肺功能
气短
Simvastatin
Chronic obstructive pulmonary disease
Lung function
Shortness of breath
