摘要
目的探讨血清S100β蛋白对急性脑梗死(ACI)的诊断价值。方法采用酶联免疫吸附法(ELISA)对150例急性脑梗死患者和50例健康对照者血清S100β蛋白含量进行检测,观察比较不同病情和不同梗死面积ACI患者在不同时点含量的变化。结果 ACI患者12 h血清中的S100β蛋白含量高于健康对照组,差异有统计学意义(t=2.30,P<0.05);150例ACI重度、中度患者在入院后24、36、48、72 h血清S100β蛋白明显高于12 h轻度患者(P<0.05);150例ACI大面积、小面积患者在入院后24、36、487、2 h血清S100β蛋白明显高于12 h腔隙性梗死患者(P<0.05)。结论血清S100β蛋白可能是预测ACI患者病情严重程度及预后的重要指标之一。
Objective To study the significance of the detection of serum S100β protein in the diagnosis of acute cerebral infarction（ACI）.Methods The contents of serum S100β protein in 150 patients with ACI and 50 healthy participants were detected by enzyme-linked immunosorbent assay（ELISA）.The changes of S100β protein were compared with patients of different pathogenetic conditions and infarction size.Results The level of serum S100β protein in the ACI patients within 12 h was apparently higher than that of control group（t=0.23,P0.05）;The level of serum S100β protein in 150 patients with moderate and severe ACI were significantly higher than that of the mild group after 24 h,36 h,48 h,72 h（P0.05）.And the level of serum S100β protein in 150 patients with massive and small size infarction area after 24 h,36 h,48 h,72 h was significantly higher than that of the patients with cerebral lacuna infarct within 12 h（P0.05）.Conclusion The serum S100β protein may be one of the important index to predict the serious degrees and prognosis of ACI.
出处
《检验医学与临床》
CAS
2011年第14期1731-1732,1734,共3页
Laboratory Medicine and Clinic
