摘要
目的探讨上皮性卵巢癌中FHIT、survivin和PTEN的表达情况及其与卵巢癌临床病理特征、预后的关系。方法运用免疫组化S-P法检测60例上皮性卵巢癌、52例正常卵巢组织中FHIT、survivin和PTEN蛋白表达情况。结果上皮性卵巢癌中FHIT、survivin和PTEN阳性表达率分别为51.7%、73.3%、53.3%,正常卵巢组织中分别为84.6%、15.4%、76.9%;随着卵巢癌临床分期增高、分化程度减低、有淋巴结转移survivin表达呈上升趋势,而FHIT、PTEN表达呈下降趋势;FHIT与sur-vivin呈负相关(r=-0.624,P<0.01),与PTEN呈正相关(r=0.719,P<0.01)。结论 FHIT、survivin和PTEN异常表达与上皮性卵巢癌的发生发展密切相关,3项指标的联合检测可作为上皮性卵巢癌早期诊断及预测预后具有较高临床参考价值的指标。
Objective To detect the expression of FHIT,survivin and PTEN genes in epithelial ovarian cancer, and to investigate their relationship with clinicopathologic significance and prognosis. Methods FHIT,survivin and PTEN protein were detected in 60 cases of epithelial ovarian cancer, 52 normal ovarian tissue by immunohistochemistry using streptavidin -peroxidase （SP） method. Results The positive expression rate of FHIT,survivin and PTEN were re spectively 51.7% ,73.3% ,53.3% in epithelial ovarian cancer cases, 4.6% , 15.4% ,76.9% in normal ovarian tissue. The expression of FHIT,survivin and PTEN was significantly correlated with clinicopath- ologic stages,levels of differentiation and and lymphnode metastasis. The FHIT and survivin factors were negative correlative, and the ex- pression of PTEN was positive correlative in epithelial ovarian neoplasm. Conclusion The abnormal expression of FHIT, survivin and PTEN may play an important role in the initiation and development of epithelial ovarian cancer. The combined detection of FHIT, survivin and PTEN is helpful for the early diagnosis and evaluating the prognosis of the disease.
出处
《医学研究杂志》
2011年第7期133-136,共4页
Journal of Medical Research
