摘要
目的研究长时间使用吸入糖皮质激素对慢性阻塞性肺疾病(COPD)合并糖尿病患者糖代谢的影响。方法选择合并Ⅱ型糖尿病的肺功能Ⅲ～Ⅳ级COPD缓解期患者92例,长期吸入沙美特罗/氟替卡松干粉剂,观察治疗前及治疗3个月、半年后患者肺功能(FEV1、FEV1%)和空腹血糖、糖化血红蛋白、胰岛素、C-肽指标改变。结果使用吸入皮质激素3个月、半年后肺功能与治疗前比较有统计学意义(P<0.05),同时糖代谢指标与治疗前差异无统计学意义(P>0.05)。结论长期吸入糖皮质激素对合并糖尿病的COPD患者糖代谢无明显影响。
Objective To study the effect of prolonged use of inhaled corticosteroids on glucose metabolism of patients with chronic obstructive pulmonary disease（COPD） combined Diabetes.Methods 92 patients of pulmonany function Ⅲ-Ⅳ grade COPD combined type 2 diabetes mellitus were treated with long-term inhalation of salmeterol/fluticasone dry powder.The lung function（FEV1,FEV1%）,fasting blood glucose,glycated hemoglobin,insulin and C-peptide were observed.Result Use of inhaled corticosteroids 3 months,six months The lung function before and after treatment was statistically significant different（P0.05）,while the difference of glucose metabolism indexes was not statistically significant before and after treatment（P0.05）.Conclusion Long-term inhaled corticosteroids on COPD patients with diabetes has no effect on glucose metabolism.
出处
《西部医学》
2011年第7期1321-1321,1323,共2页
Medical Journal of West China
