摘要
目的分析比较TSH、T3、FT3、T4及FT4在甲状腺功能紊乱患者体内的变化情况及临床意义。方法应用全自动电化学发光分析仪检测2008年3月~2008年12月3643例门诊、住院患者血清中的TSH、T3、FT3、T4及FT4五种激素水平,按出现结果的方式组合进行统计,并从诊断甲亢和甲低两方面分别统计五种指标的阳性率。结果在诊断甲亢方面,五种指标的阳性率从高到低分别是TSH(27.31%)〉FT3(16.91%)〉FT4(16.55%)〉T3(14.08%)〉T4(7.99%);在诊断甲低方面,五种指标的阳性率从高到低分别是TSH(20.72%)〉FT4(11.61%)〉FT3(10.38%)〉T4(10.29%)〉T3(9.11%)。结论无论是在诊断及指导治疗甲亢还是甲低,TSH都是一项非常灵敏的指标,诊断甲亢时,FT3要优于FT4,在诊断甲低方面,FT4要优于FT3,同时游离类激素比总激素能更好地反映甲状腺功能的实际水平;而五种指标的联合使用,对甲状腺疾病的诊断及治疗用药都有非常重要的指导作用。
Objective To analyze and compare the change of TSH、T3、FT3、T4 and FT4 and the clinical meaning in thyroid function disorder patients.Methods TSH、T3、FT3、T4 and FT4 in 3643 patients'serum samples were detected by automatic electrochemiluminescence analyzer from Mar to Dec in 2008.Results The positive rate of these five index in graves patients aligned from high level to low level were TSH(27.31%)FT3(16.91%)FT4(16.55%)T3(14.08%)T4(7.99%),and in hypothyroidism patients the sequence were TSH(20.72%)FT4(11.61%)FT3(10.38%)T4(10.29%)T3(9.11%).Conclusion No matter in hyperthyroidism or hypothyroidism,TSH was a most sensitive diagnosis parameter.And it was helpful to combine these five parameters in diagnosis and treatment of thyroid disease.
作者
李尔凡
严海燕
钟丽玲
罗晓红
LI Er-fan,YAN Hai-yan,ZHONG Li-ling,LUO Xiao-hong(1.Department of Clinical Laboratory,BoJi-affiliated hospital of Sun Yat-sen University,Guangzhou 511300;2.Department of Clinical Laboratory,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou 510120;3.Department of Clinical Laboratory,Blood Station of Zengcheng City,Guangzhou 511300,China)
出处
《医学信息》
2011年第13期4150-4152,共3页
Journal of Medical Information
关键词
甲状腺功能
检测指标
组合模式
诊断价值
thyroid gland function
detection parameter
combination model
diagnosis value