摘要
目的比较异甘草酸镁与复方甘草酸单胺治疗血液肿瘤化疗后药物性肝损害的临床疗效与不良反应。方法选取48例血液肿瘤化疗后药物性肝损害患者,随机分为2组,各24例。异甘草酸镁组予异甘草酸镁注射液150 mg,复方甘草酸单胺组予复方甘草酸单胺注射液60 mL,2组试剂均加入5%葡萄糖注射液250 mL静滴,每日1次,疗程均为2周。观察治疗后临床症状、体征、肝功能改善情况及不良反应。结果 2组治疗后临床症状、体征及肝功能指标较治疗前均有明显改善,改善率无显著性差异(P>0.05),但在复常天数上有显著性差异(P<0.05)。异甘草酸镁组显效率明显高于复方甘草酸单胺组(P<0.05)。异甘草酸镁组未出现明显不良反应;复方甘草酸单胺组发生颜面部水肿4例,血压升高1例。结论异甘草酸镁治疗血液肿瘤化疗后药物性肝损害的疗效优于复方甘草酸单胺,且副作用显著低于复方甘草酸单胺。
Objective To compare the clinical effect and adverse reactions of Magnesium Isoglycyrrhizinate（MI） and Compound Ammonium Glycyrrhetate（CAG） on drug-induced liver injury（DILI） after blood cancer chemotherapy.Methods Forty-eight cases of DILI after blood cancer chemotherapy were divided into two groups.The patients in MI group（n=24） were given MI injection 150 mg,while CAG group（n=24） was given CAG injection 60mL.Both groups were added 250 mL 5% glucose injection,once every day,and continually vein injected for 2 weeks.Results After two weeks,the symptoms and liver function parameters of two groups were significantly improved,and the rates of improvement had no significant differences（P0.05）,but the improving dates had significant differences（P0.05）.The effectual rate of MI group was significantly higher than that of CAG group（P0.05）.No obvious adverse reactions were found in MI group,while four cases of facial edema,one case of high blood pressure were found in CAG group.Conclusion The clinical effect of MI on DILI after blood cancer chemotherapy is better than that of CAG.The rate of adverse reactions of MI is significantly lower than that of CAG.
出处
《实用临床医药杂志》
CAS
2011年第13期18-20,共3页
Journal of Clinical Medicine in Practice
关键词
异甘草酸镁
复方甘草酸单铵
血液肿瘤
药物性肝损害
Magnesium Isoglycyrrhizinate
Compound Ammonium Glycyrrhetate
blood cancer
drug-induced liver injury
