期刊文献+

自体造血干细胞移植治疗多发性骨髓瘤疗效分析 被引量:2

下载PDF
导出
摘要 目的观察采用高剂量化疗联合自体造血干细胞移植治疗多发性骨髓瘤与VAD方案的疗效比较。方法 1999~2010笔者所在科收治多发性骨髓瘤患者29例分两组。A组:4周期VAD方案后进行高剂量化疗联合自体造血干细胞移植治疗。B组:采用VAD方案6周期。结果 A组CR率42·9%(6/14例)显著高于B组的13·3%(2/15例),差异有显著性(P〈0·01)。A、B两组有效率(完全缓解+缓解)78%(11/14例)和40%(6/15例),差异有显著性(P〈0·01)。结论 高剂量化疗联合自体造血干细胞移植治疗多发性骨髓瘤疗效的疗效优于常规VAD化疗。
机构地区 湖南省肿瘤医院
出处 《中外医学研究》 2011年第20期28-29,共2页 CHINESE AND FOREIGN MEDICAL RESEARCH
  • 相关文献

参考文献4

  • 1Attar M, Harousseau JL, Stoppa A, ct al. A prospective randomzed trial of autologous bone marrow transplantation and chemtherapy in multiple myeloma. N Engl J Med, 1996,335 (2) :91 - 97. 被引量:1
  • 2Attar M, Harousseau JL, Stoppa A, et al. A prospective high dose therapy in multiple myeloma an updated analysis of the IFM9Oprotocol. Blood, 1998,92 ( Supp 11 ) :418 - 422. 被引量:1
  • 3Lenhoff S, Hjorth M, Turrsson I, et al. Intensive therapy for multi- ple myeloma in patients younger than 60 years. Long - term re- sults focusing on the effect of the degree of response on survival and replapse patern after transplantation. Haematologiea,20(O ,91 (9) :1228 - 1233. 被引量:1
  • 4Child JA, Morgan G J, Davies FE, et al. High - dose chemotherapy with hematopoietic stem - cell rescue for multiple myeloma. N Engl J Med,2003,348(19) :1875 -1888. 被引量:1

同被引文献48

  • 1苗瑞新.造血干/祖细胞动员临床研究新进展[J].国际移植与血液净化杂志,2006,4(3):32-35. 被引量:2
  • 2Cavo M,Rajkumar SV,Palumbo A. International Myeloma Working Group consensus approach to the treatment of multiple myeloma patients who are candidates for autologous stem celltransplantation[J].{H}Blood,2011,(23):6063-6073. 被引量:1
  • 3Koreth J,Cutler CS,Djulbegovic B. High-dose therapy with single autologous transplantation versus chemotherapy for newly diagnosed multiple myeloma:A systematic review and meta-analysis of randomized control ed trials[J].{H}Biology of Blood and Marrow Transplantation,2007,(02):183-196. 被引量:1
  • 4Lentzsch S,O'Sul ivan A,Kennedy RC. Combination of bendamustine,lenalidomide,and dexamethasone (BLD) in patients with relapsed or refractory multiple myeloma is feasible and highly effective:results of phase 1/2 open-label,dose escalation study[J].{H}Blood,2012,(20):4608-4613. 被引量:1
  • 5Eom HS,Min CK,Cho BS. Retrospective comparison of bortezomib-containing regimens with vincristine-doxorubicin-dexamethasone (VAD) as induction treatment prior to autologous stem celltransplantation for multiple myeloma[J].{H}Japanese Journal of Clinical Oncology,2009,(07):449-455. 被引量:1
  • 6Rosi?ol L,Oriol A,Teruel AI. Superiority of bortezomib,thalidomide,and dexamethasone (VTD) as induction pretransplantation therapy in multiple myeloma:a randomized phase 3 PETHEMA/GEM study[J].{H}Blood,2012,(08):1589-1596. 被引量:1
  • 7Mikhael JR,Reeder CB,Libby III EN. Results From the Phase II Dose Expansion of Cyclophosphamide, Carfilzomib, Thalidomide and Dexamethasone(CYCLONE)in Patients with Newly Diagnosed Multiple Myeloma[J].Blood(ASH Annual Meeting Abstracts),2012.445. 被引量:1
  • 8Roussel M,Moreau P,Huynh A. Bortezomib and high-dose melphalan as conditioning regimen before autologous stem celltransplantation in patients with de novo multiple myeloma:a phase 2 study of the Intergroupe Francophone du Myelome (IFM)[J].{H}Blood,2010,(01):32-37. 被引量:1
  • 9Perrone CM,Ceccolini G,Lauta M. Superiority of Double over Single Autologous Stem-cellTransplantation for Newly Diagnosed Multiple Myeloma and Prognostic Impact of Complete Response:Final Analysis of"Bologna 96"Study[J].Blood(ASH Annual Meeting Abstracts),2007.730. 被引量:1
  • 10Martinez-Lopez J,Blade J,Mateos MV. Long-term prognostic significance of response in multiple myeloma after stem celltransplantation[J].{H}Blood,2011,(03):529-534. 被引量:1

引证文献2

二级引证文献11

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部