摘要
目的观察复方丹参注射液联合生长抑素治疗急性胰腺炎（AP）的疗效。方法 56例AP患者随机分为对照组（26例）和治疗组（30）,其中对照组患者在常规治疗基础上给予生长抑素静脉泵注治疗,治疗组在对照组基础上加入复方丹参注射液静脉滴注。观察比较两组患者临床症状改善情况,血尿淀粉酶,血钙等生化指标检查,及并发症发生率、病死率、中转手术率和平均住院时间。结果 （1）治疗组痊愈率和总有效率分别为33·33%、90·00%,明显优于对照组19·23%的痊愈率和80·77%的总有效率,两组间比较差异有统计学意义（P〈0·01或0·05）;（2）经过治疗,所有患者血淀粉酶水平降低,血钙水平升高,且治疗组比对照组变化显著（P〈0·01或0·05）,尤以治疗后3~7d更为明显;（3）治疗组患者腹痛腹胀缓解时间,血尿淀粉酶和白细胞计数恢复时间显著短于对照组（P〈0·01或0·05）;（4）治疗组与对照组患者间病死率比较差异无统计学意义（P〉0·05）,但治疗组并发症发生率、中转手术率和平均住院时间均少于对照组,两组间比较差异有统计学意义（P〈0·01或0·05）。结论 复方丹参注射液联合生长抑素治疗急性胰腺炎能减轻胰腺损伤,缩短疗程,减少并发症,降低手术率和病死率,疗效优于生长抑素单独使用。
Objective To observe the therapeutic effect of compound salvia mihiorrhiza combined with somatostatin on patients with acute pancreatitis（AP）.Methods 56 cases with AP were divided randomly into control group （26 cases） and treatment group（30 cases）.In the control group, patients were taken routine measures and intravenous injection of somatostatin with subsequent intravenous pump.On the above treatment of the control group,the treatment group was added with intravenous injection of compound salvia miltiorrhiza.The change of symptoms, urine and serum amylase,serum calcium concentration were analyzed and compared,as well as incidences of complication,fatality and the time in hospital.Results （1）The cure rate and total effect rate were 33.33% and 90.00% respectively in treatment group,significantly higher than 19.23% and 80.77% in the control group （P0.01 or 0.05）.（2）After treatment,the levels of serum amylase significantly decreased,while serum calcium concentration significantly increased in all patients,especially in treatment group on day 3-7（P0.01）.（3）The treatment group was significantly faster in relief of stomachache and abdominal distension than control group,along with recovery of urine and serum amylase and WBC count （P0.01 or 0.05）.（4）There was significant difference in incidence of complication,operation conversion and the hospital stay between the two groups （P0.01 or 0.05）,but not in fatality incidence（P0.05）.Conclusion Combination of compound salvia mihiorrhiza,somatostatin could reduce pancrease injure,complications,operation rate and mortality,and shorten the course of treatment,which is better than somatostatin alone.
出处
《中外医学研究》
2011年第20期1-3,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
急性胰腺炎
生长抑素
复方丹参注射液
Acute pancreatitis
Somatostain
Compound salvia mihiorrhiza
