摘要
目的探讨3种根除幽门螺杆菌(HP)方案的临床疗效及安全性。方法选择经快速尿素酶确诊HP感染的171例患者,随机分为3组,每组选用1种治疗方案进行治疗。其中A组患者给予埃索美拉唑20 mg每日2次+左氧氟沙星0.5 g每日1次+阿莫西林1.0 g每日2次,共7 d;B组患者给予埃索美拉唑20 mg每日2次+阿莫西林1.0 g每日2次(第1～5日);埃索美拉唑20 mg每日2次+克拉霉素0.5 g每日2次+替硝唑0.4 g每日2次(第6～10日);C组:埃索美拉唑20 mg每日2次+阿莫西林1.0 g每日2次(第1～5日);埃索美拉唑20 mg每日2次+左氧氟沙星0.5 g每日1次+替硝唑0.4 g每日2次(第6～10日),疗程结束4周后复查HP。结果 A组根除率为87.3%,B组根除率为92.6%,C组根除率为96.2%。A组与B组、C组根除率比较,差异均有统计学意义(P<0.05),B组与C组根除率比较,差异无统计学意义(P>0.05)。3组不良反应比较差异无统计学意义。结论 3种方案中,B组、C组采用的治疗方案根治率高于A组治疗方案,B组和C组治疗方案在此次试验中差异无统计学意义。
Objective To evaluate the efficacy and safety of three kinds of thiple strategy of Helicobacter pylori（HP） eradication.Methods A total of 171 patients who suffered from HP infection,confirmed by 13C-urea breath test（UBT）,were randomly divided into 3 groups,Each group was randomly treated with one of the A,B,C strategy,and named as group A,group B,group C.Group A was treated with Esomeprazole,Levofloxacin,Amoxicillin,group B was treated with Esomeprazole,Amoxicillin（1-5 days）,Esomeprazole,Clarithromycin and Tinidazole（6-10 days）,and group C was treated with Esomeprazole,Amoxicillin（1-5 days）,Clarithromycin,Levofloxacin and Tinidazole（6-10 days）.HP was detected by UBT at the fourth week after treatment.Results HP eradication rates of group A,B and C,were 87.3%,92.6%,96.2%,respectively.The difference between Group A and Group B,Group A and Group C was significant（P0.05）.There was no statistical difference between the eradication rate of Group B and C,and among the side effects of the 3 groups.Conclusion Among the three strategies,B and C,which can be used clinically,are better than A,while B and C have no statistical difference.
出处
《实用临床医药杂志》
CAS
2011年第11期60-62,共3页
Journal of Clinical Medicine in Practice
关键词
幽门螺杆菌
序贯疗法
Hp eradication
sequential regimen
