摘要
目的探讨骨髓涂片和骨髓活检同步对比分析在血液病诊断中的意义。方法收集1989—2009年沈阳军区总医院2761例血液疾病患者,骨髓样本采用骨髓抽吸、活检同步法取材,骨髓涂片与活检染色后,行增生程度及细胞形态学观察。结果在急性白血病(AL)、再生障碍性贫血(AA)、原发性骨髓纤维化(PMF)、骨髓转移癌(MCBM)、多发性骨髓瘤(MM)、慢性淋巴细胞白血病(CLL)、慢性粒细胞白血病(CML)、骨髓增殖性疾病(MPD)及恶性淋巴瘤的诊断符合率,骨髓活检高于骨髓涂片(P<0.05);对于白血病的分型、特发性血小板减少性紫癜(ITP)的诊断符合率,骨髓涂片高于骨髓活检(P<0.05)。骨髓活检在监测PMF和继发性骨髓纤维化疾病的骨髓增生程度及纤维化程度占显著的优势。结论在血液疾病的诊断中骨髓活检和骨髓涂片各具优缺点,两者的结合对提高疾病的诊断率有重要的价值。
Objective To investigate the significance of bone marrow aspiration and bone marrow biopsy double examinaions for diagnosis of hematological diseases. Methods The 2761 cases with hematologic diseases were analyzed retrospectively, bone marrow specimens were obtained by bone marrow aspiration and biopsy with the same-step method. Marrow aspiration were routinely stained with Wright staining, while marrow biopsy specimens were embedded in plastic were stained with Hematoxylin-Giemsa-Aeid Fuehsine（HGF） and Gomori reticular fiber staining,in order to process the hyperplasia degree and morphocytology observation. Results In acute leuke- mia （ AL）, aplastie anemia （ AA）, primary myelofibrosis （ PMF）, metastatic carcinoma of bone marrow （ MCBM ）, multiple myeloma （ MM ） , chronic lymphocytic leukemia （ CLL ） , chronic myelogenous leukemia （ CML ） , myelopro- liferativc disorders（MPD） and malinant lymphoma, of which the diagnosis rate of marrow biopsy exceed marrow aspiration（ P 〈0. 05 ）. while marrow aspiration exceed marrow biopsy, including the typing in acute leukemia （AL） and the diagnosis rate of idiopathic thromboeytopenic purpura（ITP） （P 〈 0.05 ）. Bone marrow biopsy has a promi- nent in monitoring bone marrow hyperplasia and fibrosis degree. Conclusion Bone marrow biopsy and aspiration have the themselves advantage and disadvantage aspects, by whose combination has the important value improving the diagnosis rate of diseases.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2011年第7期536-538,共3页
Chinese Journal of Practical Internal Medicine
