摘要
目的:通过研究金刚藤有效部位群对慢性盆腔炎模型大鼠子宫组织中炎症介质(PGE2、组胺和5-羟色胺)的影响,探讨金刚藤有效部位群的抗炎作用机理。方法:用苯酚胶浆注入大鼠子宫造成大鼠慢性盆腔炎模型,给药后用酶联免疫法检测大鼠子宫组织中PGE2的含量,用荧光法测定大鼠子宫组织中组胺和5-羟色胺的含量。结果:金刚藤有效部位群能够显著减少慢性盆腔炎模型大鼠子宫组织中PGE2、组胺和5-羟色胺的含量。结论:金刚藤有效部位群抑制PGE2、组胺和5-羟色胺等炎症介质的合成及释放是其发挥抗炎作用的机理之一。
Objective：To study the anti-inflammation mechanism of Jingangteng＇s effective ingredients（JGTEI）by assaying the prostaglandin E2（PGE2）,5-hydroxytrptamine（5-HT）and histamine（HA）in uterus of chronic pelvic inflammation rats.Methods：The models of chronic pelvic inflammation disease（CPID）rats were made by injection of brei admixed with Phenol and tragacanth into the uterus of rats,the PGE2,5-HT and HA contents in the uterus of CPID rats were measured by enzyme-linked immunosorbent assay（ELISA）and fluorescence spectrophotometry.Results：JGTEI can significantly decrease the level of PGE2,5-HT and HA in the uterus of CPID rats.Conclusion：Decreasing the level of inflammatory media may be one of the anti-inflammation mechanisms of JGTEI.
出处
《辽宁中医杂志》
CAS
北大核心
2011年第7期1334-1336,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金(30870256)
关键词
金刚藤
有效部位群
慢性盆腔炎
炎症介质
Jingangteng
Effective ingredients
Chronic Pelvic inflammation
Inflammatory media
