摘要
目的观察丹红注射液治疗不稳定型心绞痛(UAP)的疗效,及对炎症因子的影响。方法将70例UAP患者随机分为治疗组和对照组各35例。对照组给予阿司匹林、氯吡格雷、硝酸酯类、低分子肝素、β-受体阻滞剂、钙离子拮抗剂、他汀类药物等,治疗组在此基础上加用丹红注射液,1次/d。两组治疗均为2周,观察患者临床症状改善情况及血清高敏C-反应蛋白(hs-CRP)水平。结果治疗后治疗组和对照组的总有效率分别为91.43%和65.71%,治疗组明显优于对照组(P<0.01)。两组患者hs-CRP较治疗前明显下降,治疗组更为明显(P<0.01)。治疗组在用药过程中未见不良反应。结论丹红注射液显著改善不稳定型心绞痛患者的临床症状,并能抑制炎性反应,防止斑块破裂,是辅助治疗不稳定型心绞痛的一种安全有效的药物。
Objective To observe the therapeutic effect of DANHONG injection on the unstable angina pectoris（UAP） and inflammatory factor. Methods Seventy patients with UAP were randomly divided into treatment group （ n = 35 ） and control group （ n = 35 ）, both groups were treated with the conventional treatment of aspirin, clopidogrel, nitrate esters, low molecular weight heparin, 13-blockers, calcium channel antagonist and statins etc. The treatment group was given DANHONG injection once a day for two weeks based on the conventional treatment. After two weeks, the improvement of symptom and the changes of high-sensitivity C-reactive protein were observed. Results The total effective rate of the two groups was 91.43 % and 65.71%, respectively. The treatment group was better than the control group obviously（ P 〈 0.01 ）. The serum levels of hs-CRP were reduced after treatment, especially in treatment group（P 〈 0.01 ）. There was no obvious adverse reaction in the treatment group. Conclusion DAN- HONG injection can improve the elinieal symptom of patients with UAP,inhibit the inflammatory response and prevent rupture of plaque. It is a safe ,effective medicine in the adjuvant therapy of UAP.
出处
《中华全科医学》
2011年第8期1239-1240,共2页
Chinese Journal of General Practice
关键词
不稳定型心绞痛
丹红注射液
炎症因子
Unstable angina pectoris
Danhong injection
Inflammatory factor
