摘要
目的了解学生大规模接种甲型H1N1流感疫苗的免疫效果及影响因素,为探索甲型H1N1流感免疫策略和防控措施提供科学依据。方法分别对344名中学生在甲型H1N1流感疫苗接种前及接种后1个月采集血清标本,进行抗体水平的检测。并收集中学生在接种疫苗前季节性流感疫苗接种史、流感样症状等有关流行病学信息,评价甲型H1N1流感疫苗的免疫效果及影响因素。结果 344名中学生在免前H1N1流感抗体几何平均滴度（GMT）为1∶16.97（95%CI：1∶14.49~1∶19.86）,抗体阳性率为36.50%（95%CI：31.35%~41.89%）;免后GMT为1∶167.41（95%CI：1∶145.08~1∶193.18）,阳性率为89.91%（95%CI：86.19%~92.91%）,阳转率为72.54%（95%CI：67.76%~77.32%）,均明显高于免前。接种疫苗前3个月的季节性流感疫苗接种史、流感样症状史等因素分组后,各组间免疫学效果指标间差异无统计学意义（P〉0.05）。结论接种甲型H1N1流感疫苗后免疫成功率70%以上,符合欧盟和美国FDA的有关规定,免疫效果良好。季节性流感疫苗接种史、流感症状史等对疫苗的免疫学保护效果无明显影响。
Objective To understand the immunogenicity and influence factors of the influenza A（H1N1） vaccine in mass immunization,providing evidence for decision making on immunization strategy and control of influenza A（H1N1）.Methods Serologic samples from 344 subjects were collected,tested and analyzed before and 1 month after influenza A（H1N1） vaccine immunization.Positive rates,sero-conversion rates,GMT（geometric mean titer） of antibody,history of influenza-like illness and seasonal influenza vaccination were calculated and compared between different groups.Results Positive rate of antibody was 36.50%（95%CI： 31.35%~41.89%）,and GMT was 1∶16.97（95%CI： 1∶14.49~1∶19.86） at baseline.After immunization,positive rate was 89.91%（95%CI： 86.19%~92.91%）,sero-conversion rates was 72.54%（95%CI： 67.76%~77.32%） and GMT was 1∶167.41（95%CI：1∶145.08~1∶193.18）,which were significantly higher than those before immunization,and there were no significant differences among different groups divided by history of influenza-like illness and seasonal influenza vaccination（P0.05）.Conclusion The vaccine proved to be highly immunogenic,and it could achieve the criteria of EMEA and FDA.The history of influenza-like illness and seasonal influenza vaccination did not influence the immune effect of this vaccine.
出处
《浙江预防医学》
2011年第7期5-7,17,共4页
Zhejiang Journal of Preventive Medicine
基金
浙江省医药卫生科技计划项目(2010KYA054)
