摘要
妊娠期高血压疾病是妊娠期特有疾病,迄今仍是孕产妇和围生儿死亡的主要病因之一。子痫前期是该病的常见和主要的发病类型,其病因和发病机制至今尚未完全阐明。国外学者利用活体妊娠动物模型深入研究,从分子细胞层面揭示了螺旋动脉重铸的过程,主要包括绒毛外滋养细胞的侵入及其介导的血管平滑肌细胞和内皮细胞的凋亡,提出许多影响这一过程的因素,将其与子痫前期发病的相关性进行深入探索,总结许多假说和推论,完善了子痫前期胎盘缺血缺氧的假说。现就细胞分子生物学机制与子痫前期发病的相关性研究综述。
Hypertensive disorders is a specific disease that occurs in pregnancy,which is still one of the main causes of maternal and neonatal death up till now.Pre-eclampsia is the most common and major type of this disease.Its etiology and pathogenesis have not been fully understood.At present,foreign scholars have revealed the process of extravillous trophoblast invasion and spiral arterial remodeling in vivo at the molecular and cellular level,mainly including the extravillous trophoblast invasion and the cell apoptosis of vascular smooth muscle cells and endothelial cells.A number of factors that impair this progress have been put forward.An in-depth study in their correlation with the pathogenesis of pre-eclampsia proposes many hypotheses and inferences,and make perfect the hypotheses of ischemia and hypoxia of placenta.This article reviews the development of this process and the correlation with pathogenesis of pre-eclampsia in recent years.
出处
《国际妇产科学杂志》
CAS
2011年第3期174-177,共4页
Journal of International Obstetrics and Gynecology
关键词
绒毛膜绒毛
滋养层
先兆子痫
胎盘
缺血
缺氧
Chorionic villi
Trophoblasts
Pre-eclampsia
Placenta
Ischemia
Anoxia
