摘要
目的:探讨还原型谷胱甘肽(reduced glutathione,GSH)治疗糖尿病酮症酸中毒(diabetic ketoacidosis,DKA)患者时对氧化应激的影响。方法:将47例DKA患者分为常规治疗组23例,加用GSH治疗组24例,检测2组患者治疗前后血超氧化物歧化酶(superoxide dismutase,SOD)活性、总抗氧化能力(total antioxidant capacity,TAC)、丙二醛(malondialdehyde,MDA)和晚期蛋白氧化产物(advanced oxidation protein products,AOPP)含量。结果:DKA患者应用GSH治疗后SOD和TAC均显著升高,且与常规治疗组治疗后差异均有统计学意义(P<0.01),而治疗后AOPP较则明显降低,与常规治疗组治疗后差异有统计学意义(P<0.01)。结论:GSH在治疗DKA时可明显降低氧化应激水平,对机体有保护作用。
Objective ：To investigate the effect of reduced glutathione on oxidative stress in diabetic ketoacidosis （DKA） patients. Methods：Forty-seven cases of DKA patients were divided into two groups randomly： conventional treatment group and plus reduced glutathione treatment group. The levels of superoxide dismutase （ SOD ）, total antioxidant capacity （ TAC ）, malondialdehyde （ MDA ）, advanced oxidation protein products（AOPP） of the two groups were compared before and after treatment. Results： After treatment by plus reduced glutathione, the content of SOD, TAC were increased significantly when compared with that in the conventional group（ P 〈 0. 01 ）, however, the level of AOPP was decreased significantly（ P 〈 0. 01 ）. Conclusions：Reduced glutathione could reduce the level of oxidative stress in DKA, and thus protect the body.
出处
《蚌埠医学院学报》
CAS
2011年第6期600-601,605,共3页
Journal of Bengbu Medical College
