摘要
目的：评价含左氧氟沙星的三联方案治疗幽门螺杆菌的有效性和安全性及不同疗程的疗效。方法：将幽门螺旋杆菌（Helicobacter pylori,H pylori）阳性的患者263例随机分为克拉霉素治疗组和阿莫西林治疗组,各组按不同疗程分为5、7、10、14d亚组,两组联合的抗菌药均含左氧氟沙星,抑酸剂选用雷贝拉唑。各组在治疗前1周内和治疗后4~8周分别检测H pylori感染情况。结果：含左氧氟沙星的三联方案H pylori根除率为81.0%,克拉霉素治疗组H pylori根除率与阿莫西林治疗组比较无统计学差异（P〉0.05）,随着疗程的增加根除率也增加,7、10、14d亚组要明显高于5d亚组,但10、14d亚组之间无统计学意义（P〉0.05）;两组随着疗程的增加不良反应的发生率均增加,但克拉霉素组总的发生率要略高于阿莫西林组;在临床症状缓解方面,两组之间无统计学意义（P〉0.05）,但各组随着疗程的增加缓解率也增加,但10d与14d亚组的临床症状缓解率之间无统计学意义（P〉0.05）。结论：含左氧氟沙星的雷贝拉唑联合克拉霉素或阿莫西林是安全有效的幽门螺杆菌根除方案,7、10、14d疗程均可获得好的疗效,综合根除率、不良反应发生率和临床症状缓解率,10d疗程最佳。
Objective: To evaluate the efficacy and safety of the triple with levofloxacin in different courses in the treatment of Helicobacter pylori.Methods: 263 cases of Helicobacter pylori-positive patients were randomly divided into amoxicillin treatment group and clarithromycin treatment group,each group is divided into different treatment subgroups by 5,7,10,14days.The two groups received the anti-bacterial drugs of levofloxacin and antacid of Rabeprazole.Before the treatment within one week and after the treatment in 4-8 weeks,Helicobacter pylori infection was detected.Results: Helicobacter pylori eradication rate was 81.0%;clarithromycin treatment group and amoxicillin treatment group showed no significant difference;With the course increase also increased the eradication rate of helicobacter pylori;7,10,14days subgroup was significantly higher than the 5-day subgroup;in the 10-day subgroup and 14-day subgroup there was no statistical significance;the incidence of adverse reactions increased with the course increase;clarithromycin group was slightly higher than the amoxicillin group;in clinical remission,there was no statistical significance between the two groups,but in each group with the increase in course,remission rate also increased;10-day and 14-day sub-group had no statistical significance in the remission rates of clinical symptoms.Conclusion: Rabeprazole levofloxacin with clarithromycin or amoxicillin joint is safe and effective for the eradication of H pylori.7,10,14days course can get a good effect.In terms of eradication,incidence of adverse reactions and remission of clinical symptoms,10-day course is seen as the best for treatment.
出处
《长江大学学报（自然科学版）》
CAS
2011年第6期147-149,159,共4页
Journal of Yangtze University(Natural Science Edition)
