摘要
目的探讨选择性髂内动脉灌注化疗(简称"介入化疗")对子宫内膜癌术后盆腔复发的疗效。方法回顾2005-2008年16例子宫内膜癌术后盆腔复发病例,所有病例均行介入化疗4～6个疗程,对比其临床症状及影像学肿瘤的变化,并观察生存期。结果随访6个月,3例临床症状完全缓解,6例明显缓解,4例中度缓解,2例轻度缓解,1例无临床症状,临床症状总缓解率达60.0%(9/15);CR2例,PR5例,SD7例,PD2例,近期有效率为43.8%(7/16);4例获二次手术切除,占25.0%,随访3年生存率56.3%(9/16)。结论介入化疗对子宫内膜癌术后盆腔复发病灶有较好的近期疗效,可改善临床症状,缩小肿瘤体积,提高二次手术切除机会。
Objective To evaluate the therapeutic effect of selected internal iliac arterial infusion chemotherapy（IAIC） in the patients with pelvic recurrence of endometrial cancer.Methods 16 cases with endometrial cancer which underwent hysterectomy and were found pelvic recurrence between 2005 and 2008 were reviewed.All the patients were treated with IAIC 4 to 6 times.The clinical symptoms,imaging change of tumor,and survival time were observed.Results At the follow-up period of 6 months,the clinical symptoms in 3 cases were relieved completely,6 cases obviously,4 cases partially,and 2 cases slightly respectively.1 case had no clinical symptoms.The total relieve rate of clinical symptoms was 60.0%（9/15）.Of those tumor masses,CR in 2 cases,PR in 5 cases,SD in 7 cases,and PD in 2 cases,the recently effective rate was 43.8%（7/16）.4 cases underwent secondary operation,accounting for 25.0%.The 3-year survival rate was 56.3%（9/16）.Conclusion IAIC can relieve clinical symptoms,decrease the tumor size,and increase the opportunity of secondary operation in pelvic recurrence of endometrial cancer,with a good short-time result.
出处
《海南医学》
CAS
2011年第13期20-22,共3页
Hainan Medical Journal
基金
深圳市重点学科项目资助(编号:2001B07)
关键词
子宫内膜癌
术后复发
动脉灌注化疗
介入化疗
介入治疗
Endometrial cancer
Recurrence
Arterial infusion chemotherapy
Interventional chemotherapy
Interventional therapy
