摘要
目的探讨乳头状淋巴管内血管内皮细胞肿瘤的临床病理特征、诊断及鉴别诊断。方法对2例乳头状淋巴管内血管内皮细胞肿瘤的组织病理学、免疫组织化学结果进行观察分析,并复习相关文献。结果 2例表现均为皮下肿块伴疼痛。光镜下肿瘤呈海绵状血管瘤样改变,囊性扩张的薄壁血管腔内被覆靴钉样内皮细胞,并呈乳头状、肾小球样突入管腔内,核分裂相少见。免疫组化示:瘤细胞CD31(+)、CD34(+)、FVIIIRag(+)、Vimetin(+)、CK(-)、NSE(-)。结论乳头状淋巴管内血管内皮细胞肿瘤是罕见的血管源性肿瘤,有独特的病理特征,免疫组化可协助诊断。应与其他血管源性肿瘤相鉴别。
Objective To investigate the clinical pathological features,diagnosis and differential diagnosis of papillary intralymphatic angioendothelioma（PILA）.Methods Observe and analyze the histopathology,immunohistochemistry features of PILA,and review relative literatures.Results Chief complain of the two case were subcutaneous mass with pain. Tumor in microscopy was cavernous hemangioma like changes;the expansion of thinner wall cystic cavity covered with boots nail like vascular endothelial cells,and with papillary and glomerular like changes protruded into lumen,rare mitotic was found.Immunohistochemical results showed the tumors was positive in CD31,CD34,FⅧRag and vimentin,and negative in CK and NSE.Conclusion PILA is extremely rare vascular disease.It has unique pathology and immunohistochemistry features which can be helpful for the diagnosis and differentiation from other vascular tumors.
出处
《疑难病杂志》
CAS
2011年第2期107-109,F0003,共4页
Chinese Journal of Difficult and Complicated Cases
