摘要
目的观察双参田七散(SSTQ)对大鼠动脉粥样硬化(atherosc lerosis,AS)的防治作用。方法应用高脂饲料联合维生素D3建立动脉粥样硬化模型,将52只SD大鼠随机分成空白组、模型组、双参田七散组及辛托伐他汀组,第12周检测大鼠血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、丙二醛(MDA)、超氧化物歧化酶(SOD)的水平,并用电镜观察主动脉弓的超微结构。结果双参田七散组血清TC、TG、LDL-C、MDA较模型组显著降低(P<0.01,P<0.05);双参田七散组血清SOD较模型组显著升高(P<0.01);双参田七散组主动脉病变程度与模型组比较明显减轻。结论双参田七散对AS有防治作用,可能机理是通过改善脂质代谢、抗自由基氧化损伤而防止主动脉内膜损伤。
Objective To observe the effect of Shuangshen Tianqi pulvis（SSTQ） on the rat model of atherosclerosis.Methods The animal model of atherosclerosis was established by feeding high-fat diet and vitamin D3.Male SD rats were randomly assigned into normal group,model group,SSTQ-treated group and simvastatin-treated group.The serum levels of total cholesterol（TC）,low density lipoprotein cholesterol（LDL-C）,high density lipoprotein cholesterol（HDL-C）,triglyceride（TG）,malonaldehyde（MDA） and superoxide dismutase（SOD） were measured after 12 weeks.Meantime,the ultrastructure of aortic arch was observed under the electron microscope.Results Compared to the model group,serum levels of TC,TG,LDL-C and MDA were significantly decreased（P〈0.01 or P〈0.05）,and serum SOD level was remarkably increased（P〈0.01） in SSTQ-treated group.The pathological damage of aortic arch was also markedly ameliorated in SSTQ-treated group.Conclusion The protective effect of SSTQ on the rat model of atherosclerosis is related to regulating the lipid metabolism,suppressing oxygen free radical damage,and preventing aortic intimal injury.
出处
《广东药学院学报》
CAS
2011年第3期292-295,共4页
Academic Journal of Guangdong College of Pharmacy
基金
广州市中医名科建设项目(穗卫中[2010]5号)
