摘要
目的 探讨阿立哌唑与奥氮平对精神分裂症患者血脂、血糖及泌乳素的影响.方法 收集符合CCMD-3标准的精神分裂症患者44例,其中阿立哌唑组19例（男6例,女13例）,奥氮平组35例（男11例,女24例）,以阿立哌唑15～30 mg/d,奥氮平10～20mg/d剂量治疗6个月.分别于服药前及服药后第15、30、90、180天进行血脂、血糖及泌乳素的检测并比较.结果 治疗前后各时点甘油三脂和高密度脂蛋白的组间差异均无统计学意义（均P ＞0.05）;胆固醇的组间差异在治疗第15、90、180天均有统计学意义（均P〈0.05）;低密度脂蛋白和血糖的组间差异在治疗第180天有统计学意义（P＜0.05）;泌乳素的组间差异在治疗第30、90、180天均有统计学意义（均P＜0.05）.结论 阿立哌唑相比奥氮平对胆固醇的影响较小,长期治疗过程中,对低密度脂蛋白、血糖及泌乳素的影响也较小,而两者对甘油三酯及高密度脂蛋白的影响相似.
Objective To evaluate the effects of aripiprazole and olanzapine on blood lipids, glucose and prolactin levels of patients with schizophrenia. Methods Forty five patients with schizophrenia were enrolled in the study. All subjects met the criteria of CCMD-3 and were separated into aripiprazole group （N=19, 6 males and 13 females） and olanzapine group （N=36, 11 males and 24 females）. Blood lipids, glucose, and prolactin levels were tested in 0, 15, 30, 60, 90 and 180 days after treatment. Results The differences of triglyceride and high density lipoproteins between two groups were not significant （P 〉0.05） at any time point. There was significant difference in levels of cholesterol between two groups at d15, d90 and d180 after treatment （P〈0.05）. The levels of low density lipoprotein and blood glucose in aripiprazole group were significantly lower than those in olanzapine group at d180 （P 〈0.05）. And there was significant difference in levels of prolactin between two groups at d30,d90 and d180 （P〈0.05）. Conclusion Aripiprazole has less effect on the levels of blood cholesterol, low density lipoprotein, glucose and prolactin in schizophrenic patients compared to olanzapine.
出处
《浙江医学》
CAS
2011年第6期810-812,共3页
Zhejiang Medical Journal
基金
浙江省医药卫生科学研究基金（2009A034）
