摘要
目的:建立大鼠缺血性面神经瘫痪(面瘫)动物模型,观察面神经表面毛细血管。方法:选择性地阻塞颌内动脉,术后第1天和第30天处死动物,通过心脏灌注荧光染料,在荧光显微镜下观察面神经表面毛细血管。结果:颌内动脉栓塞后5～15min出现面瘫,并可观察到面神经表面血管变细,甚至被阻塞,尤以迷路段为甚。术后30天面瘫基本恢复,面神经表面血管也基本恢复正常,仅偶见血管变细。结论:这一动物模型的建立。
Objective:In order to establish animal model for ischemic facial nerve palsy in rats and to observe the intrinsic vascular network of facial nerve in the fallopian canal.Method: Selective vascular embolization of the external carotid artery was performed in rats. The animals were killed at 1 and 30 days after operation respectively.10% gelatin solution with fluorescent dye were injected into their left ventricles. The changes intrinsic vascular network were observed under inverted fluorescent microscopy. Result:Facial palsy was presented within 5 to 15 min following arterial embolization,the intrinsic capillaries of facial nerve appeared to be thinner and some of them were blocked by microspheres,especially in the labyrinthine segment. Facial palsy almost recovered after 30 days postoperatively. The capillaries returned to be almost normal shape and only few of them were thinner.Conclusion:The establishment of animal model for ischemicfacial palsy will make contribution to experimental research and clinical treatment for facial palsy.
出处
《临床耳鼻咽喉科杂志》
CSCD
1999年第10期464-465,共2页
Journal of Clinical Otorhinolaryngology
