摘要
目的:探讨反复发作的分泌性中耳炎(OME)患儿腺样体和中耳积液中的IgE是否存在相关性。方法:选取35例OME患儿为实验组,31例腺样体肥大患儿为对照组,实验组取中耳积液和腺样体标本,对照组取腺样体标本,其中腺样体标本制成组织匀浆,用酶联免疫分析技术测定腺样体和中耳积液中IgE的含量。运用SPSS 18.0统计软件对所有相关数据进行处理分析。结果:实验组腺样体和中耳积液中IgE的含量比对照组明显增高(P<0.05)。实验组中耳积液和腺样体中IgE的含量呈直线正相关(r=0.580,P<0.05)。结论:OME的发生与免疫因素有关,肥大腺样体内的Ⅰ型免疫反应增强,可能与OME的反复发作、迁延不愈有关。
Objective：To study the expression of IgE in recur repeatedly children otitis media with effusion（OME）,and the relativity of IgE between adnoid and middle ear effusion.Method：Thirty-five cases diagnosed of OME in our department,were enrolled in the research.Thirty-one adenoidal hypertrophy cases were selected as control group.Obtained middle ear effusion and adnoid samples from experimental group,and obtained adnoid samples from control group.All adnoid samples were taken for tissue homogenate.Determination all samples of concentration of IgE by ELISA.SPSS 18.0 statistical software was used for all relevant data processing and analysis.Result：Compared the IgE content between experimental group and control group with adnoid samples,IgE content increased significantly in experimental group（P0.05）,and IgE in experimental group of middle ear effusion samples were also increased（P0.05）.The content of IgE in the experimental group of middle ear effusion and adnoid assumed straight-line correlation,in negative correlation（r=0.580,P0.05）.Conclusion：The occurrence of OME is related to immune factors.Adnoidal hypertrophy may lead to local immunity enhancement,may cause middle ear cavity immune system abnormality,give rise to recur repeatedly with OME and procrastinates does not recover.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2011年第13期588-589,共2页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
关键词
中耳炎
分泌性
腺样体
中耳积液
IGE
media with effusion
otitis
adnoid
middle ear effusion
IgE
