摘要
目的:探讨C反应蛋白(CRP)与2型糖尿病(T2DM)大血管病变发生的关系。方法:将T2DM患者60人随机分为合并大血管并发症组与无大血管并发症组,每组各30例,正常对照组30例。检测病人血清中血脂、糖化血红蛋白(HbA1c)和CRP水平。结果:2型DM患者的CRP水平明显高于正常对照组(P<0.05),其中有大血管并发症组显著高于无大血管并发症组(P<0.05),Logstic回归分析显示,CRP水平是T2DM患者大血管并发症发生的独立危险因素。结论:CRP与T2DM的发生相关,升高的CRP是促使T2DM并发大血管病变的独立危险因素。
Objective： To explore the correlation of c-reactive protein（CRP） 1eve1 and diabetic macroangiopathy in type 2 diabetic patients.Methods： Sixty diabetic patients and thirty normal were divided into patient with diabetic macroangiopathy grouop,patient without diabetic macroangiopathy group and control group.Hemoglobin A1c（HbA1c）,total cholesterol（TC）,triglycerides（TG） and sensitivity CRP were assessed in all variables.Results： Level of CRP was different in three groups significantly（P0.05）.The CRP level of patient with diabetic macroangiopathy was increased significantly,compared with patient without diabetic macroangiopathy（P0.05）.Multiple stepwise regression analysis showed CRP was important contributors to diabetic macroangiopathy.Conclusion： CRP is associated with the development of type 2 diabetes.Increased CRP is an independent risk factor for diabetic macroangiopathy with type 2 diabetes.
出处
《四川生理科学杂志》
2011年第2期65-67,共3页
Sichuan Journal of Physiological Sciences
关键词
2型糖尿病
糖尿病大血管病变
C反应蛋白
Type 2 diabetes
Diabetic vascular complications
C-reactive protein
