摘要
犬细小病毒(Canine parvovirus,CPV-2)首次分离于1978年,被认为是由遗传关系相近的猫泛白细胞减少症病毒(FPLV)或其他肉食兽细小病毒(FPLV-like virus)跨宿主感染犬产生的新病原。其感染能引起新生犬急性心肌炎或幼犬出血性肠炎,造成较高的发病率和死亡率。该病原爆发后短短一年时间内即广泛流行到世界各地。随着CPV-2对宿主的适应和变异,新抗原变异型(CPV-2a、CPV-2b和CPV-2c)不断产生并在世界各地逐步替代了CPV-2的流行。伴随CPV-2抗原变异的同时,其对宿主(犬、猫)嗜性、毒力等生物学特性也随之改变。本文综述了CPV-2过去30多年在世界流行和变异情况,并探讨了基因变异在病毒跨宿主传播中的意义。
Canine parvovirus（CPV-2）,first recognized in 1978 as a new pathogen of dogs,was probably derived from a very closely related virus in cats,feline panleukopaenia virus（FPLV） or a closely related carnivore parvovirus（FPLV-like virus）.CPV-2 is responsible for either myocarditis or fatal gastroenteritis in pups with high morbidity and mortality.Shortly after its emergence,CPV-2 has become endemic in the global dog population.The original CPV-2 continued to evolve,and was subsequently replaced by three different but closely related antigenic variants,designated CPV-2a,CPV-2b and CPV-2c,which now coexist in dog populations worldwide.The genetic and antigenic variation in CPV-2 also correlated with changes in the host range and tissue tropisms of the virus.Here,we reviewed variation and evolution of CPV-2 in past 30 years and discussed CPV-2 as an important model to study virus evolution.
出处
《微生物学报》
CAS
CSCD
北大核心
2011年第7期869-875,共7页
Acta Microbiologica Sinica
基金
吉林省科技发展计划农业重大专项(20075024)~~
关键词
犬细小病毒
进化
抗原变异
canine parvovirus
evolution
antigenic mutation
