摘要
用单克隆抗体、ABC法对10例寻常型泛发性进行期银屑病患者初发皮损中单个核细胞进行分析,发现初发皮损内增多的单个核细胞以T淋巴细胞为主,巨噬细胞次之,并且大部分呈DR^+,未见B淋巴细胞,表皮内DR^+树枝状细胞和DR^+角朊细胞常与其周斟DR^+T淋巴细胞位置很接近,说明银屑病的发生与细胞免疫紊乱密切相关。
The mononuclear cells in early skin lesions of 10 patients with extensive psoriasis vulgaris in progressive stage were studied by biotin-avidin-peroxidase method using monoclonal antibodies. The results show that increased mononuclear cells in the early skin lesions, expressing HLA-DR antigen mostly, consist of T lymphocytes and macrophases with a preponderance of T lymphocytes, B lymphocytes are absent, activated T lympocytes are usually in close proximity to DR^+ cells including dentritic cells and keratinocytes, indicating that the initial psoriatic lesion correlates closely with imbalance of cellular immunity.
出处
《西安医科大学学报》
CSCD
1990年第4期363-365,共3页
Journal of Xi'an Medical University(Chinese)
关键词
牛皮癣
淋巴细胞亚群
病因
psoriasis
early skin lesion
lymphocyte subsets
