摘要
目的:比较改良磷酸钙骨水泥(CPC)与普通CPC修复兔桡骨骨缺损的效果,并探讨其作为修复骨缺损植骨替代材料的可行性。方法:新西兰大白兔36只随机分为改良CPC组,普通CPC组和对照组。3组均于双侧桡骨中下段制作骨缺损,改良CPC组植入改良CPC棒,普通CPC组植入普通CPC棒,对照组不植入任何物质。于术前、术后2、4、8、12周检测3组血清中Ca2+、P3-、碱性磷酸酶(ALP)浓度;分别于术后2、4、8、12周对3组行X光摄片;术后8、12周分批处死之,取桡骨标本做扫描电镜。结果:术后12周改良CPC组骨缺损修复良好,骨水泥完全降解;普通CPC组新骨形成相对较少,骨水泥残留;改良与普通CPC组术后血清中Ca2+及ALP浓度比有统计学意义(P<0.05);扫描电镜观察显示改良CPC组骨修复完全,可见材料与宿主骨原交界面。结论:改良CPC较普通CPC有更好的骨缺损修复能力及生物降解性。
Objective：To evaluate the effect of modified calcium phosphate bone cement（CPC）and coercial CPC in repairing rabbit radius bone defects,and to discuss the feasibility of modified CPC as bone substitution materials.Me-thods：The animal models of bilateral radius bone defects were establisbed in thirty-six New Zealand white rabbits,which were randomly classificated for modified CPC,coercial CPC and control groups.The modified CPC rods were implanted into bone defects areas in the modified CPC group,the coercial CPC rods were implanted into bone defects areas in the coercial CPC group and the bone defects with no implants were used as blank control group.A series of examinations were carried out.The radiography was carried out at the second,4th,8th and 12th weeks after operation.The specimens were harvested separately at the end of 8th and 12th weeks after operation for scanning electron microscope observation.Results：By the end of 12th week after operation,the bone defects in the modified CPC group were repaired better and the bone cement was completely degradated,compared with the poor osteogenesis in the coercial CPC group.The serum concentration of calcium and ALP in the modified CPC group was significantly higher than that of coercial CPC group（P〈0.05）.The original borderline between modified CPC and host bone still could be distinguished when the repairing of bone defects finished.Conclusion：The modified CPC possesses better osteoinducibility and faster rate of degradation than coercial CPC in repairing bone defects.
出处
《汕头大学医学院学报》
2011年第2期91-94,F0002,共5页
Journal of Shantou University Medical College
基金
广东省科技计划资助项目(2008B080701033
2009B080701040)
广东省自然科学基金博士启动基金资助项目(8451503102001818)
关键词
磷酸钙骨水泥
骨缺损
兔
calcium phosphate bone cement
bone defect
rabbit
