摘要
[目的]了解血栓性微血管病(Thrombotic microangiopathy,TMA)的临床特征及治疗,结合文献探讨其发病机制以加深对该病的认识。[方法]对9例TMA患者的临床表现特点、治疗及预后进行回顾性分析。[结果]患者主要临床表现为微血管病性贫血(9/9),血小板减少(9/9),乳酸脱氢酶升高(9/9),不同程度的肾脏损害和中枢神经系统症状(9/9),发热(5/9);6例治愈,3例死亡。[结论]TMA起病急、进展快、死亡率高、预后差,应提高对本病的认识,早诊断、早治疗、减少死亡率。
[Objective] To study the clinical characteristics and treatment of thrombotic microangiopathy（TMA） for improve recognition of TMA,combined with reviewing literatures.[Methods] Clinical data including manifestation,treatment and prognoses of 9 patients with TMA admitted to our hospital between January 2007 and December 2010 were analyzed retrospectively.[Results] The clinical manifestation was characterized by microangiopathic hemolytic anemia（9/9）,thrombocytopenia（9/9）,elevated serum LDH value（9/9）,renal damage and neurological abnormalitics（9/9） and fever（5/9）.Six of the patients were cured and 3 of them died.[Conclusion] TMA is a kind of severe acute syndrome with high mortality and bad prognosis.We should improve recognition of TMA for quick diagnosis and treatment in order to obtain better efficacy and less mortality.
出处
《大连医科大学学报》
CAS
2011年第3期248-252,共5页
Journal of Dalian Medical University
关键词
血栓性微血管病
临床分析
发病机制
thrombotic microangiopathy
clinical analysis
pathogenesis
