摘要
生物人工肝支持系统借助体外的机械、生化装置,清除患者体内积蓄的各种有害物质,补充有利于肝细胞再生的必需物质,改善内环境,暂时替代患者病肝的部分功能,为肝衰竭患者过渡到自身肝细胞再生或肝移植赢得宝贵的时间。在生物人工肝支持系统(BALSS)中,生物反应器是整套系统的核心。对生物反应器中多参数如溶解氧(DO)、pH和温度的有效控制是保障肝细胞生长和功能发挥的基础,其中溶解氧对细胞生长尤为重要。文中对反应器中增加溶解氧浓度的方法、溶解氧的检测和溶解氧的控制算法进行了综述,并介绍了适用于生物人工肝溶解氧控制的自适应预测算法。
Bio-artificial liver support system（BALSS） can not only temporarily remove the waste of patients and provides essential material for hepatocytes regeneration,but also is able to ameliorate in vivo environment and restore partial function of livers in the patients with liver failure.Based on in vitro mechanical,chemical and biological devices,BALSS provides precious time for patients′ transition from liver failure to in vivo herpatocytes regeneration and liver transplantation.Bioreactor is the core of the entire bio-artificial liver support system and effective controll of the bioreactor′s operation parameters such as dissolved oxygen（DO）,pH and temperature is the basic requirement of the hepatocytes′ growth and physiology function performing.In this paper,the methods to increase the DO in bioreactor,DO detection and DO control algorithms are reviewed,and at last an adaptive predictive algorithm of DO in BALSS is introduced.
出处
《中国生物医学工程学报》
CAS
CSCD
北大核心
2011年第3期462-467,共6页
Chinese Journal of Biomedical Engineering
基金
国家高技术研究发展(863)计划(2006AA02A141)
