摘要
目的观察奥沙拉嗪对溃疡性结肠炎(UC)患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和白细胞介素-8(IL-8)的影响。方法将70例UC患者随机分成对照组和治疗组,每组35例。对照组患者予柳氮磺吡啶治疗,治疗组患者予奥沙拉嗪治疗,疗程均为8周。观察治疗前后临床症状、结肠镜下黏膜改变以及血清TNF-α、IL-6和IL-8水平的变化。结果治疗组患者临床疗效与对照组比较,差异无统计学意义(P>0.05);两组患者血清TNF-α、IL-6和IL-8水平均较治疗前显著降低(P<0.01),但治疗组下降更明显。结论奥沙拉嗪治疗UC疗效显著,并可降低患者血清TNF-α、IL-6和IL-8水平,抑制炎症反应,可能是其治疗UC的机制之一。
Objective To study the influence of olsalazine on serum TNF-α,IL-6 and IL-8 in patient with ulcerative colitis（UC）.Methods Seventy UC patients were randomly divided into control group and treatment group with thirty-five patients in each group.Both groups were given salazosulfapyridine（SASP）,while the patients of the treatment group were given olsalazine,treated for eight weeks.The clinical symptoms and colonoscopy results were assessed and serum levels of TNF-α,IL-6 and IL-8 were measured before and after treatment.Results Compared with control group,the clinical curative effect of treatment group had no statistics signifcance（P0.05）.Serum levels of TNF-α,IL-6 and IL-8 were significantly decreased in both group after treatment（P0.01）,while the declining of the serum levels of the three cytokines in treatment group was more obvious than that in control group.Conclusion There was significant effect of olsalazine on patients with UC.It may play its role by reducing the serum levels of TNF-α,IL-6 and IL-8 and inhibiting inflammatory reaction.
出处
《中华全科医学》
2011年第7期1054-1054,1128,共2页
Chinese Journal of General Practice
