摘要
目的:探讨以谷氨酰胺为代表免疫营养剂在急性重症胰腺炎临床治疗中的作用。方法:急性重症胰腺炎患者60例,其中28例常规治疗患者作为对照组,32例患者在常规治疗的基础上使用谷氨酰胺为观察组。通过比较患者入院时与治疗1周后的急性生理学与慢性健康状况评分I(IAPACHE II)中急性生理学评分、血清生化指标变化、肠道功能恢复时间、ICU治疗天数等指标研究两组疗效差异。结果:两组在年龄、性别、入院时病情危重程度上无明显差别,在治疗过程中6例病人在非手术治疗过程中转手术,4例患者因病情加重死亡。与对照组相比,观察组患者治疗1周后的心率、呼吸频率、白细胞计数、PaO2和APACHE II评分以及肠道恢复时间、ICU治疗天数与对照组相比均有显著性差异。结论:急性重症胰腺炎病人在常规治疗的基础上加用谷氨酰胺可以促进肠道功能恢复,有效减轻全身炎症反应综合征,缩短住院天数。
Objective： To investigate the clinical effects of immune nutritional agent glutamine in patients with severe acute pancreatitis.Methods：60 patients with severe acute pancreatitis were divided into control group that the patients accepted conventional treatment（28 cases） and observative group that the patients used glutamine treatment in addition to the routine treatment（32 cases）.Some changings after treatment of 1 week were compared in 2 groups,such as the acute physiology score of APACHE II system,biochemical items in serum,recovery time of intestinal function,morbitity of peripancreatic infection,days of staying in ICU.Results：The gender,age and severity of illness on admission were no significant difference in two groups.After treatment of 1 week,6 cases converted to surgery during non-operative treatment,and 4 patients died.The heart rate,breath rate,count of leucocytes,PaO2 and APACHE II score in observative group were better compared with those in control group,as well as early recovery of intestinal function and shorting time of staying in ICU were shown in observative group.Conclusion：It could promote recovery of bowel function,reduce the systemic inflammatory response syndrome and shorten ICU staying time that patients with severe acute pancreatitis treated by conventional therapy assistanting with glutamine.
出处
《天津医科大学学报》
2011年第2期227-229,共3页
Journal of Tianjin Medical University
关键词
免疫营养剂
谷氨酰胺
急性重症胰腺炎
Immune nutritional agent
Glutamine
Acute severe pancreatitis
